RN given refers to (5 alpha,6 alpha)-isomer
Also Known As:
desmethylmorphine; normorphine hydrochloride; normorphine perchlorate; normorphine sulfamate
Networked: 13 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1. Contracture
10/01/1984 - "Pertussis toxin treatment also reduced naloxone-precipitated withdrawal contractures in normorphine-dependent tissues. "
02/01/1984 - "Other peptides and alkaloids tested for ability to block the neurotensin contractures included the enkephalins, beta-endorphin, normorphine and the ketocyclazocines; all these opioids inhibited in a dose-dependent fashion the neuronal component of the excitatory effect of neurotensin. "
08/01/1981 - "No response to this dose of naloxone was induced either by incubation in control solution without opiate for 2-24 h or by exposure of the preparation to opiate for 30 min at 37 degrees C.2 When segments were incubated for 24 h, the size of the response to naloxone was directly related both to the normorphine concentration in the incubation fluid (0.01 to 0.1 muM), and to the concentration of naloxone applied (0.03 to 0.1 muM).3 A spontaneous withdrawal contracture was elicited in ilea that had been incubated with normorphine (1.0 muM), when the normorphine-containing bathing fluid was exchanged for one without opiate.4 Normorphine restored to resting level the tension of the withdrawal contracture, whether it had been elicited spontaneously or by naloxone challenge.5 Addition of naloxone (1.0 muM) to normorphine (1.0 muM) in the incubation fluid abolished the withdrawal contracture to subsequent challenge with naloxone.6 Naloxone elicited a contracture from segments incubated for 24 h at 22 degrees C with levorphanol (0.1 muM) but not from those incubated with dextrorphan.7 Application of (+)-naloxone (0.03 muM) to segments previously incubated with normorphine (0.1 muM) did not elicit a contracture.8 The contracture elicited by naloxone in preparations incubated with morphine (10 muM) was associated with a reduction in sensitivity to the acute inhibitory effect of morphine on the electrically-evoked response.9 Addition of hyoscine (0.5 muM) immediately after challenge with naloxone restored the tension of the withdrawal contracture to resting level.10 Tetrodotoxin (3.0 muM) given before challenge, prevented naloxone from eliciting a withdrawal contracture.11 The inclusion of 5-hydroxytryptamine (10 muM) with morphine (10 muM) inhibited the induction of tolerance to morphine.12 These experiments, together with those described earlier, indicate that incubation with opiate induces a dependence in the final cholinergic motor neurones of the myenteric plexus, manifested as a contracture of the longitudinal muscle on removal of opiate or administration of an antagonist. "
06/01/1981 - "Incubation of the ileum with clondine (1.0 mum) for 0.5 h at 37 degrees C did not increase responsiveness to phentolamine.2 The increase in responsiveness to phentolamine was directly related to the clonidine concentration in the incubation fluid over the range 0.01 to 1.0 mum.3 The magnitude of the contracture to phentolamine of ilea incubated with clonidine (1.0 mum) (withdrawal contracture) was directly related to the challenge dose of phentolamine over the range 0.3 to 1.0 mum.4 Yohimbine (1.0 mum) or piperoxane (1.0 mum) elicited a response comparable to that elicited by phentolamine but propranolol (1.0 mum) was inactive.5 Addition of phentolamine (1.0 mum) to clonidine (1.0 mum) in the incubation fluid abolished the increased response of the preparation to subsequent challenge with phentolamine.6 Addition of hyoscine (0.5 mum) immediately after challenge with phentolamine restored the tension of the withdrawal contracture to its resting level.7 Tetrodotoxin (3.0 mum) given before challenge, prevented phentolamine from eliciting a withdrawal contracture.8 Ileal segments incubated with clonidine (1.0 mum) were unresponsive to challenge with naloxone (100 nm); and segments incubated with normorphine (1.0 mum) were unresponsive to phentolamine (1.0 mum), although responsive to naloxone.9 Normorphine (1.0 mum) restored to resting level the tension of the clonidine withdrawal contracture; and clonidine (0.1 mum) restored to resting level the tension of the contracture to naloxone in ileal segments incubated with normorphine.10 These experiments indicate that incubation with clonidine induces, in the final cholinergic motor neurones of the myenteric plexus of the isolated ileum, a dependence the withdrawal from which is expressed as a contracture in response to alpha-adrenoceptor antagonists.11 Although opiate receptors are not involved in clonidine dependence nor alpha-adrenoceptors in opiate dependence, the findings that normorphine suppresses the clonidine withdrawal-contracture and that clonidine suppresses the contracture of opiate-dependent ileum to naloxone, suggest that the withdrawal effect studied in both clonidine and normorphine dependence in this preparation is mediated by release of acetylcholine from the final motor neurone."
2. Stupor
3. Mydriasis
4. Miosis
5. Seizures (Seizure)

Related Drugs and Biologics

1. Morphine (MS Contin)
2. Naloxone (Narcan)
3. Tetrodotoxin (Tetradotoxin)
4. Scopolamine (Hyoscine)
5. Clonidine (ST 155)
6. Pertussis Toxin
7. Yohimbine (Yocon)
8. Serotonin (5 Hydroxytryptamine)
9. Opioid Receptors (Opioid Receptor)
10. Adrenergic Receptors (Adrenergic Receptor)