crotamine

11/01/2020 - "• Synthetic crotamine increases survival of mice bearing tumor."
11/01/2020 - "• Synthetic crotamine shows tumor growth inhibition in vivo. "
11/01/2020 - "Among the properties and biological activities of crotamine, the most extraordinary is its ability to enter cells with unique selective affinity and cytotoxic activity against actively proliferating cells, such as tumor cells. "
01/01/2020 - "Crotamine Cell-Penetrating Nanocarriers: Cancer-Targeting and Potential Biotechnological and/or Medical Applications."
01/01/2018 - "Co-Localization of Crotamine with Internal Membranes and Accentuated Accumulation in Tumor Cells."

01/01/2018 - "The efficacy of crotamine in inhibiting the melanoma growth in vivo, even after passing through the gastrointestinal tract of the animal, was confirmed here. "
09/01/2011 - "In vivo crotamine cytotoxic effects in C57Bl/6J mice bearing B16-F10 primary cutaneous melanoma were tested, with two groups each containing 35 mice. "
09/01/2011 - "Crotamine toxicity and efficacy in mouse models of melanoma."
11/05/2023 - "Intraperitoneal or oral administration of crotamine:SBA-15 in a murine melanoma model suggested the potential to reduce the frequency of crotamine doses without compromising efficacy. "
01/01/2014 - "In vivo, using a murine melanoma model, it was shown that crotamine delays tumor implantation, inhibits tumor cells proliferation, and also increases the survival of mice engrafted with subcutaneous melanoma. "

04/01/2013 - "On the treadmill evaluation, rats showed significant improvement in exercise tolerance, characterized by a decrease in the number of fatigue episodes after 2 weeks of a single-dose treatment with crotamine. "

07/01/2012 - "In the past, several studies have attempted to elucidate the exact molecular target responsible for the crotamine-induced skeletal muscle spasm. "
03/06/2000 - "Native crotamine and RP-HPLC fractions F2 and F3 produced skeletal muscle spasms and spastic paralysis in mice. "
09/15/2005 - "Crotamine induces skeletal muscle spasms, leading to spastic paralysis of the hind limbs of mice, by interacting with sodium channels on muscle cells. "
01/01/2005 - "This crotamine-like protein isolated here and that named as Cro 2 produced skeletal muscle spasm and spastic paralysis in mice similarly to other crotamines like proteins. "
09/01/2012 - "Crotamine, a highly basic myotoxic polypeptide (molecular mass 4881 Da) isolated from the venom of the Brazilian rattlesnake Crotalus durissus terrificus, causes skeletal muscle contraction and spasms, affects the functioning of voltage-sensitive sodium channels by inducing sodium influx and possesses antitumour activity, suggesting potential pharmaceutical applications. "

01/01/2022 - "Crotamine is a rattlesnake-derived toxin that causes fast-twitch muscle paralysis. "
01/01/2018 - "Herein, we concomitantly performed in vitro and in vivo assays to show for the first time the dose-dependent response of crotamine-triggered hind limbs paralysis syndrome, up to now believed to be observable only at high (sub-lethal) concentrations of crotamine. "
09/15/2007 - "Hypothetically, this makes these muscles more sensitive to crotamine and would explain such hind-limb paralysis. "
03/01/2000 - "Crotamine induces paralysis in extension of hind legs of mice and myonecrosis in skeletal muscle cells. "
01/01/2022 - "Here, we characterize synthetic crotamine and show that, like the venom-purified toxin, it induces hindlimb muscle paralysis by affecting muscle contraction and inhibits KCNA3 (Kv1.3) channels. "