17-beta-hydroxy-7 alpha-methyl-androst-5-en-3-one

synthetic anti-progestational steroid; with anti-uterotrophic and gonadotropin-inhibiting activity; structure

Also Known As:

17 beta-hydroxy-7 alpha-methylandrost-5-en-3-one; 17-beta-hydroxy-7-alpha-methyl-5-androstene-3-one; RMI 12,936; RMI 12936; RMI-12936; androst-5-en-3-one, 17-hydroxy-7-methyl-, (7 alpha,17 beta)-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Androstanes: 11
      - Androstenes: 5
        Androstenols
        17-beta-hydroxy-7 alpha-methyl-androst-5-en-3-one: 3

Related Diseases

1.	Hypertrophy 09/01/1976 - "RMI 12,936 caused luteal hypertrophy in pregnant, but not pregnant hysterectomized, rats. " 09/01/1976 - "Similar hypertrophy followed administration to pseudopregnant, immature gonadotrophin-treated, and immature hysterectomized and gonadotrophin-treated rats, but the ovarian sensitivity to gonadotrophins was reduced or unchanged, suggesting that the ovarian hypertrophy is due to a direct ovarian action of RMI 12,936. " 06/01/1975 - "On Day 8 of pregnancy, RMI 12,936 resulted in significant ovarian hypertrophy, apparent within 48 hr, possibly due to a luteotrophic stimulus of placental origin. "
2.	Wounds and Injuries (Trauma) 04/01/1992 - "Subcutaneous administration of RMI 12,936 at a dose level of 2 mg/rat on day 5 of unilaterally pregnant rat having trauma-induced decidual cell reaction (DCR) in the contralateral uterine horn, suppresses DCR, induces resorption of implanted embryos and leads to decrease in the plasma level of progesterone. "

Related Drugs and Biologics

1.	Progesterone