lupeol

05/10/2022 - "This study demonstrated that lupeol could inhibit TNBC cells by inducing autophagy, suggesting lupeol as a potential treatment alternative or as a dietary supplement for TNBC, as well as offering novel insights into the anti-cancer effect of lupeol."
12/01/2016 - "More importantly, our in vivo studies showed that administration of lupeol decreased tumor growth in a dose-dependent manner and has no significant effect on the function of liver and kidney. "
01/01/2016 - "More importantly, our in vivo studies showed that administration of lupeol decreased tumor growth in a dose-dependent manner. "
04/01/2015 - "Cytotoxic studies with mouse macrophages (RAW 246.7) and HeLa cell lines revealed anti-inflammatory and anti-cancer properties for both lupeol and lupeol derivative. "
03/01/2015 - "More importantly, our in vivo studies showed that administration of lupeol decreased tumor growth in a dose-dependent manner. "

10/20/2013 - "Lupeol promoted a significant reduction of inflammation. "
11/01/2021 - "Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway."
09/15/2022 - "Amelioration of oxidative stress mediated inflammation and apoptosis in pancreatic islets by Lupeol in STZ-induced hyperglycaemic mice."
05/29/2022 - "However, the effects of lupeol on apoptosis caused by inflammation and oxidative stress in TBI have not yet been investigated. "
11/01/2021 - "Notably, our experimental results provided the support that lupeol effectively protected against LPS/D-GalN-induced acute liver injury via suppression of inflammation response and oxidative stress, which were largely dependent on the upregulation of the Nrf2 pathway via downregulating TGFβ1."

10/01/2012 - "The present study thus demonstrates the chemopreventive potential of lupeol in DMBA induced oral carcinogenesis. "
07/01/2004 - "In the present study, we show that Lupeol possesses antitumor-promoting effects in a mouse skin tumorigenesis model. "
08/01/2022 - "Moreover, lupeol suppressed tumorigenesis of xenografts in nude mice. "
10/01/2016 - "From our results DIM and lupeol would be the agent or adjunct for the treatment of bladder carcinogenesis. "
05/30/2014 - "New role of lupeol in reticence of angiogenesis, the cellular parameter of neoplastic progression in tumorigenesis models through altered gene expression."

04/01/2008 - "Our findings showed the anticancer efficacy of lupeol with mechanistic rationale against metastatic human melanoma cells. "
01/01/2014 - "In the present study, we examined the differentiation-inducing activities of lupeol on 4 canine melanoma cells in vitro and in vivo. "
12/02/2021 - "Investigation of Lupeol as Anti-Melanoma Agent: An In Vitro-In Ovo Perspective."
01/01/2019 - "Reversing effect of Lupeol on vasculogenic mimicry in murine melanoma progression."
01/01/2015 - "Clinical systemic lupeol administration for canine oral malignant melanoma."

09/15/2022 - "After diabetic induction, the animals were subjected to administration with 75 mg kg-1 body weight of lupeol, thrice a week for 7 weeks. "
02/05/2016 - "Lupeol was administered orally from 8th day upto 21st day at a concentration 25 μg/g body weight. "
01/01/2011 - "Lupeol exerted a synergistic effect without any adverse effects on body weight when combined with chemotherapeutic drugs. "
03/01/2007 - "Lupeol (25 mg/kg body weight, bw) or 1 mL of 20% w/v aqueous MPE/mouse were daily given once for 1 wk after a single dose of DMBA (50 mg/kg bw). "
10/01/2005 - "The treatment with lupeol acetate at the dose level of 10 mg/rat/day did not cause any significant change in the body weights, but significant reduction in the weight of reproductive organs, i.e. "