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lysine chloromethyl ketone

affinity label for peptides

Also Known As:

1-chloro-3,7-diaminoheptan-2-one

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Amino Acid Chloromethyl Ketones
    - lysine chloromethyl ketone: 4

Experts

1.	Foster, J D: 1 article (05/2000)
2.	Nordlie, R C: 1 article (05/2000)
3.	Stevens, A L: 1 article (05/2000)

Related Diseases

1.	Ehrlich Tumor Carcinoma 05/01/2000 - "In this study, we identify 51-kDa rat and mouse liver microsomal proteins involved in glucose-6-phosphate transport into and out of microsomal vesicles by utilizing (1) an Ehrlich ascites tumor-bearing mouse model, which displays a decreased sensitivity to the time-dependent inhibitory effect of BAEP, and (2) another glucose-6-phosphate translocase inhibitor, tosyl-lysine chloromethyl ketone, in conjunction with [(32)P]BAEP as an affinity label."
2.	Carcinogenesis 09/18/1970 - "Three synthetic inhibitors of proteases (tosyl lysine chloromethyl ketone, tosyl phenylalanine chloromethyl ketone, and tosyl arginine methyl ester) inhibit the tumorigenesis initiated in mouse skin by 7,12-dimethylbenz(a)anthracene and promoted by croton oil or its active principle, phorbol ester. "
3.	Pancreatitis 07/01/1984 - "The present paper describes the preparation of human cationic trypsin and of a stable and fully immunoreactive 125I-labelled tosyl-lysine chloromethyl ketone (TLCK) cationic trypsin by a modified chloramine-T method with a high specific radioactivity; the production of an avid and specific rabbit cationic trypsin antiserum; and a sensitive, precise, and specific radioimmunoassay method enabling measurements of fasting serum trypsin-like immunoreactivity (CTLI) in the low ng/ml range in normals; the significant rise in serum CTLI in patients with normal pancreatic exocrine secretion; and the absence of any rise in patients with severely reduced pancreatic exocrine secretion after intravenous injection of secretion; a markedly elevated fasting serum CTLI level in patients with acute pancreatitis; fasting CTLI in duodenal juice; and separation of CTLI in one minor and one major molecular component in fasting serum."
4.	Hypoxia (Hypoxemia) 04/01/1996 - "NO synthesis was potently inhibited by N-alpha-p-tosyl-lysine chloromethyl ketone and hypoxia. "

Related Drugs and Biologics

1.	Glucose-6-Phosphate
2.	Proteins (Proteins, Gene)
3.	9,10-Dimethyl-1,2-benzanthracene
4.	Trypsin
5.	Tosyllysine Chloromethyl Ketone
6.	Phorbol Esters
7.	Phenylalanine (L-Phenylalanine)
8.	Peptide Hydrolases (Proteases)
9.	Ketones
10.	Croton Oil

Related Therapies and Procedures

1.	Intravenous Injections