withanolide D

structure

Also Known As:

5,6-epoxy-4,20,22-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid delta-lactone; dihydrowithanolide D; (4 beta,5 beta,6 beta,22R)-5,6-epoxy-4,20,22-trihydroxy-1-oxoergosta- 2,24-dien-26-oic acid, delta-lactone

Networked: 11 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cuendet, Muriel: 2 articles (01/2019 - 01/2017)
2.	Ayyanar, Muniappan: 1 article (01/2022)
3.	Chand, Sharad: 1 article (01/2022)
4.	Chikhale, Rupesh: 1 article (01/2022)
5.	Dey, Yadu Nandan: 1 article (01/2022)
6.	Gurav, Nilambari: 1 article (01/2022)
7.	Gurav, Shailendra: 1 article (01/2022)
8.	Khanal, Pukar: 1 article (01/2022)
9.	Pasha, Ismail: 1 article (01/2022)
10.	Patil, B M: 1 article (01/2022)

Related Diseases

1.	COVID-19 01/01/2022 - "somnifera, Withanolide_D, Withanolide_G, Withanolide_M, and Withanolide_Q were predicted as the lead hits based on drug-likeness score, modulated proteins, and docking score to boost the immune system and inhibit the COVID-19 infection, which could primarily act against COVID-19. " 01/01/2022 - "HighlightsPlants' natural active compounds may aid in the development of COVID-19 therapeutics.MD simulation study revealed stable binding of withanolide D and withaferin A with spike proteinWithanolide D and withaferin A could be effective against SARS-CoV-2 spike protein.Discovery"
2.	Neoplasms (Cancer) 01/01/2019 - "The Withanolide D is a chemotherapeutic potential against the human tumor cell. " 01/01/2019 - "Withanolide D Enhances Radiosensitivity of Human Cancer Cells by Inhibiting DNA Damage Non-homologous End Joining Repair Pathway." 01/01/2023 - "Withanolide-D increases the radio sensitivity of human cancer cells via inhibiting deoxyribonucleic acid (DNA) damage to non-homologous end-joining repair (NHEJ) pathways. "
3.	Ulcer 10/05/2021 - "It is also an excellent rejuvenator, a general health tonic and cure for various disorders such as cerebrovascular, insomnia, asthma, ulcers, etc. Steroidal lactones (Withanolides: Withanolide A, Withaferin A, Withanolide D, Withanone, etc) isolated from this plant, possess promising medicinal properties such as anti-inflammatory, immune-stimulatory etc. Standardized root extract of the plant NMITLI-118R (NM) was prepared at CSIR-CIMAP, and was investigated for various biological activities at CSIR-CDRI. "
4.	Sleep Initiation and Maintenance Disorders (Insomnia) 10/05/2021 - "It is also an excellent rejuvenator, a general health tonic and cure for various disorders such as cerebrovascular, insomnia, asthma, ulcers, etc. Steroidal lactones (Withanolides: Withanolide A, Withaferin A, Withanolide D, Withanone, etc) isolated from this plant, possess promising medicinal properties such as anti-inflammatory, immune-stimulatory etc. Standardized root extract of the plant NMITLI-118R (NM) was prepared at CSIR-CIMAP, and was investigated for various biological activities at CSIR-CDRI. "
5.	Asthma (Bronchial Asthma) 10/05/2021 - "It is also an excellent rejuvenator, a general health tonic and cure for various disorders such as cerebrovascular, insomnia, asthma, ulcers, etc. Steroidal lactones (Withanolides: Withanolide A, Withaferin A, Withanolide D, Withanone, etc) isolated from this plant, possess promising medicinal properties such as anti-inflammatory, immune-stimulatory etc. Standardized root extract of the plant NMITLI-118R (NM) was prepared at CSIR-CIMAP, and was investigated for various biological activities at CSIR-CDRI. "

Related Drugs and Biologics

1.	withaferin A
2.	SARS-CoV-2 spike protein
3.	3- rhamnopyranosyl(1- 4)- glucopyranosyl- 12- diacetoxy- 20- hydroxywitha- 5,24- dienolide
4.	Withanolides
5.	Lactones
6.	withanone
7.	Cytostatic Agents
8.	p38 Mitogen-Activated Protein Kinases
9.	JNK Mitogen-Activated Protein Kinases
10.	Sphingomyelin Phosphodiesterase (Sphingomyelinase)

Related Therapies and Procedures

1.	Therapeutics