jervine

teratogen from Veratrum grandiflorum; RN given refers to parent cpd(3beta,23beta)-isomer; structure

Also Known As:

jervine, acetate, (3beta,23beta)-isomer; 17,23 beta-epoxy-3 beta-hydroxyveratraman-11-one

Networked: 15 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Veratrum Alkaloids: 30
    - jervine: 15

Experts

1.	Jiang, Ming: 3 articles (12/2021 - 08/2020)
2.	Wang, Huan: 3 articles (12/2021 - 08/2020)
3.	Hao, Jian-Ping: 2 articles (12/2021 - 08/2020)
4.	Qin, Yu-Ting: 2 articles (12/2021 - 08/2020)
5.	Yao, Liu: 2 articles (12/2021 - 08/2020)
6.	Zhao, Fang: 2 articles (12/2021 - 09/2020)
7.	Hossain, Mobarok: 1 article (03/2022)
8.	Limon, Belayet Hasan: 1 article (03/2022)
9.	Paul, Anjasu: 1 article (03/2022)
10.	Raza, Thosif: 1 article (03/2022)

Related Diseases

1.	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 09/05/2020 - "This study aims to investigate the roles of Sonic hedgehog (Shh) signaling pathway in the occurrence and progression of Myelodysplastic Syndrome (MDS) and further evaluate using jervine as therapeutic strategy for MDS by inhibiting Shh pathway. " 09/05/2020 - "Sonic hedgehog signaling pathway in Myelodysplastic Syndrome: Abnormal activation and jervine intervention." 08/01/2020 - "[Effect of Sonic Hedgehog Signal Pathway Inhibitor Jervine on Myelodysplastic Syndromes MUTZ-1 Cells]." 12/01/2021 - "Synergistic inhibitory effect of Smo inhibitor jervine and its combination with decitabine can target Hedgehog signaling pathway to inhibit myelodysplastic syndrome cell line."
2.	Neoplasms (Cancer) 12/01/2020 - "In this study, we attempted to explore whether Jervine (JV), an inhibitor of Hedgehog signaling, had anti-cancer effects on NPC, and the underlying mechanisms. " 12/10/2020 - "Jervine (Jer), a sterodial alkaloid from rhizomes of Veratrum album, exhibits anti-inflammatory and anti-cancer effects. "
3.	Osteoarthritis 03/01/2019 - "In inflammatory study, 50, 100, 200 and 400  mg/kg doses of jervine, 25  mg/kg doses of DIC and IND were orally administered, and the volume of the foots were measured up to their knee arthrosis by plethismometer. "
4.	Acute Erythroblastic Leukemia (Erythroleukemia) 04/15/2013 - "Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect." 04/15/2013 - "In this study, we investigated the antiproliferative and apoptotic effects of cyclopamine and jervine, two steroidal alkaloids with similar structures, on HEL and TF1a human erythroleukemia cell lines and, for the first time, their effect on COX-2 expression. "
5.	Edema (Dropsy) 03/01/2019 - "In the current study, anti-inflammatory and antioxidant effects of jervine isolated from NH4OH-benzene extract of V. album rhizomes were investigated on CAR induced paw edema in rats. " 03/01/2019 - "According to the present results, jervine exerted 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema. "

Related Drugs and Biologics

1.	Alkaloids
2.	cyclopamine
3.	Dacarbazine (DIC)
4.	Antioxidants
5.	Teratogens
6.	Biomarkers (Surrogate Marker)
7.	Melatonin
8.	Carrageenan
9.	Decitabine
10.	LY-2157299

Related Therapies and Procedures

1.	Therapeutics