heliotrine

10/01/1995 - "[Enzymatic activity of the pancreas and small intestinal mucosa in modelling of toxic hepatitis by administration of heliotrine]."
10/01/1995 - "Acute heliotrine intoxication (in a toxic hepatitis model) was shown to lead to a marked decrease in the activities of both pancreatic and intestinal enzymes. "
05/01/1986 - "Phytoecdysteroids (ecdysterone) exert more beneficial effect on the parameters under study in rats with toxic hepatitis induced by heliotrine."
04/01/1987 - "Hepatocyte membranes destruction in experimental toxic hepatitis caused by heliotrine administration was accompanied by a 10-fold increase in blood serum activity of aldolase fructose-I-monophosphate, a decrease in cytochrome P-450 content, an increase in the rate of cytochrome P-450 inactivation, as well as a decrease in microsomal glucose-6-phosphatase activity. "

01/01/1982 - "Heliotrine poisoning of broiler chickens: an experimental clinicopathologic study of low dose intoxication."
01/01/1982 - "Poisoning of 7-day-old broiler chickens with a low dose of heliotrine (10 mg/kg/day for 3 days) produced retarded rate of growth in male and female birds for a period of 14 to 21 days. "
03/01/1969 - "[Hematopoiesis in chronic heliotrine poisoning in Wistar albino rats]."
11/01/1968 - "[Phagocytosis of erythroblasts by bone marrow reticular cells in rats with chronic heliotrine poisoning]."
07/01/1962 - "Liver damage in acute heliotrine poisoning. "

03/01/1969 - "An electron-microscope study of liver cell necrosis due to heliotrine."
11/01/1989 - "Subchronic intraperitoneal administration of PAs to weanling rats and adult mice produced, in surviving animals, hepatic megalocytosis and centrilobular necrosis with heliotrine (H) and 9-O-(R(-)-2-(4'-chlorophenyl)-2-hydroxybutyryl)retronecine N-oxide (RC1NO) but only megalocytosis with INO. "
08/01/1975 - "Hence, pretreatment of rats with large doses of nicotinamide prevents the depletion of nicotinamide adenine dinucleotide coenzymes and liver necrosis in rats given heliotrine (230 mg/kg body weight)."

08/01/1975 - "Three rats of six males, surviving 22 to 27.5 months after one or two intragastric doses of the monoester pyrrolizidine alkaloid, heliotrine (230 mg/kg body weight), and pretreatment with nicotinamide (350 mg/kg body weight) by pretreatment with nicotinamide (350 mg/kg body weight) by i.p. "
08/01/1975 - "Hence, pretreatment of rats with large doses of nicotinamide prevents the depletion of nicotinamide adenine dinucleotide coenzymes and liver necrosis in rats given heliotrine (230 mg/kg body weight)."
01/01/2020 - "Therefore, a 28-day subacute rat feeding study was performed with six structurally different PA heliotrine, echimidine, lasiocarpine, senecionine, senkirkine, and platyphylline, administered at not acutely toxic doses from 0.1 to 3.3 mg/kg body weight. "

01/01/1969 - "[Morphologic signs of the participation of immunologic mechanisms in the pathogenesis of heliotrine liver cirrhosis (experimental-morphologic study)]."