diphyllin

extract of Cleistanthus collinus (Roxb), a highly poisonous plant; do not confuse with diphyllin or diphylline which is the main heading AMINOPHYLLINE; do not confuse with the theophylline derivative DYPHYLLINE

Also Known As:

Networked: 20 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wang, Dan: 2 articles (02/2020 - 10/2010)
2.	Zhu, Li: 2 articles (02/2020 - 10/2010)
3.	Zhao, Yu: 2 articles (01/2020 - 10/2010)
4.	Liu, Pengfei: 2 articles (03/2018 - 09/2011)
5.	Shen, Weidong: 2 articles (03/2018 - 09/2011)
6.	Chai, Hee-Byung: 2 articles (01/2018 - 06/2014)
7.	Chang, Wei-Shan: 2 articles (01/2018 - 10/2017)
8.	Chen, Hui-Wen: 2 articles (01/2018 - 10/2017)
9.	Chen, You-Ting: 2 articles (01/2018 - 10/2017)
10.	Fang, Zih-Syun: 2 articles (01/2018 - 10/2017)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 11/10/2017 - "This study may inform the synthesis of future Diphyllin derivatives with different apoptosis mechanism of action towards human melanoma cells." 11/01/2017 - "It was previously reported that diphyllin, a novel V-ATPase inhibitor, can inhibit the migration and invasion of SGC7901 human gastric cancer cells; however, the effects of cleistanthin A (CA), a diphyllin glycoside, on melanoma cells has not been demonstrated. "
2.	Plague (Bubonic Plague) 08/01/2020 - "In conclusion, the study identifies diphyllin as a therapeutic and dispersal agent aimed at biofilms formed by food-borne pathogens that persistently plague food processing and aquaculture settings."
3.	Human Influenza (Influenza) 01/01/2018 - "In this study, we report that nanoparticle encapsulation of diphyllin and bafilomycin improves the drugs' anti-influenza applicability. " 01/01/2018 - "In addition, following a lethal influenza viral challenge, diphyllin nanoparticle treatment conferred a survival advantage of 33%. " 01/01/2018 - "In a mouse model of sublethal influenza challenge, treatment with diphyllin nanoparticles resulted in reduced body weight loss and viral titer in the lungs. "
4.	Esophageal Neoplasms (Esophageal Cancer) 03/01/2018 - "The present study revealedthat diphyllin inhibited proliferation and induced S arrest in esophageal cancer cell lines TE-1 and ECA-109. " 03/01/2018 - "Diphyllin inhibited blood metastasis by regulating the mTORC1/HIF-1α-/VEGF pathway, therefore it could be considered as a new V-ATPase inhibitor to treat esophageal cancer."
5.	Neoplasms (Cancer) 12/05/2022 - "In pancreatic cancer xenograft model, treatment of 15 with 10 mg/kg exhibited much more potent efficacy in suppressing the growth of transplanted PANC02 tumors than diphyllin without obvious safety concern." 12/05/2022 - "The natural product diphyllin has demonstrated great potential in the treatment of various human cancers, especially pancreatic cancer. " 12/05/2022 - "Synthesis and anti-tumor activity of nitrogen-containing derivatives of the natural product diphyllin." 11/10/2017 - "Diphyllin and its derivatives are well known cytotoxic natural products structurally related to the anti-cancer drug podophyllotoxin. " 11/01/2021 - "The isolated compounds were evaluated for their in vitro cytotoxicity against human cancer cell lines, including brest cancer MCF-7, cervix carcinoma HeLa, lung cancer A549 and H460, and diphyllin (14) showed moderate cytotoxicity against the HeLa, A549 and H460 cells with IC50 of 9.13, 23.12, 42.34 µM, respectively, justicianene D showed weak cytotoxicity against the MCF-7 cell with inhibition rate of 50% at the concentration of 90 µM."

Related Drugs and Biologics

1.	Adenosine Triphosphatases (ATPase)
2.	Lignans
3.	Glycosides
4.	cleistanthin
5.	Lactones
6.	Antiviral Agents (Antivirals)
7.	tuberculatin
8.	justicidins
9.	Matrix Metalloproteinase Inhibitors
10.	TOR Serine-Threonine Kinases

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)