|1.||Dziegiel, Morten H: 2 articles (09/2012 - 10/2007)|
|2.||Henriksen, Kim: 2 articles (09/2012 - 10/2007)|
|3.||Karsdal, Morten A: 2 articles (09/2012 - 10/2007)|
|4.||Neutzsky-Wulff, Anita V: 2 articles (09/2012 - 10/2007)|
|5.||Deng, Youcai: 1 article (06/2014)|
|6.||Soejarto, Djaja D: 1 article (06/2014)|
|7.||Yu, Jianhua: 1 article (06/2014)|
|8.||Kinghorn, A Douglas: 1 article (06/2014)|
|9.||Lantvit, Daniel D: 1 article (06/2014)|
|10.||Yalowich, Jack C: 1 article (06/2014)|
10/01/2010 - "A series of benzoisoindolin hydrazones as analogues of natural lignan diphyllin were synthesized and the structures of these compounds were established by (1)H-NMR, (13)C-NMR, Mass and high resolution (HR)-MS. The compounds were evaluated for in vitro cytotoxicity against KB, A549 and HCT-116 cancer cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. "
03/01/2002 - "The known compounds justicidin A (1), diphyllin (3), and tuberculatin (4) showed potent cytotoxic effects against a number of cancer cells in vitro. "
10/01/2007 - "Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption."
10/01/2007 - "Furthermore, we found that diphyllin inhibited human osteoclastic bone resorption measured by CTX-I (IC50 = 14 nM), calcium release, and pit area, despite increasing TRACP activity, numbers of osteoclasts, and cell viability. "
10/01/2007 - "The effect of diphyllin on bone resorption by osteoclasts was measured as release of C-terminal cross-linked telopeptide of type I collagen (CTX-I) and calcium into the supernatants and by scoring pit area. "
09/01/2012 - "Mimicking the reduction in bone resorption using the V-ATPase inhibitor Diphyllin, the cysteine proteinase inhibitor E64 and the MMP-inhibitor GM6001 showed that CM from diphyllin and E64 treated osteoclasts showed reduced ability to induce bone formation compared to CM from vehicle treated osteoclasts, while CM from GM6001 treated osteoclasts equaled vehicle CM. Osteoclasts on either dentine or decalcified bone showed strongly attenuated anabolic capacities. "
06/01/1996 - "Justicidins A and B, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate showed strong antiviral activity (the MIC were less than 0.25 microgram ml-1, respectively) against vesicular stomatitis virus and low cytotoxicity (the MTC were larger than 31 micrograms ml-1, respectively) against cultured rabbit lung cells (RL-33)."
|4.||Stomach Neoplasms (Stomach Cancer)
09/30/2011 - "The natural compound diphyllin, a cytostatic lignan isolated from Cleistanthus collinus, can dramatically inhibit the proliferation and induce the apoptosis of human gastric cancer cells, SGC7901. "
09/30/2011 - "Therefore, diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling."
|5.||Hypotension (Low Blood Pressure)
|1.||Adenosine Triphosphatases (ATPase)
|4.||Cysteine Proteases (Cysteine Protease)
|5.||Collagen Type I (Type I Collagen)