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2-naphthylaminomethyl-gamma-aminobutyric acid (A 144)

Also Known As:

A 144; A-144; 4-(((2-naphthalenylamino)methyl)amino)butanoic acid

Networked: 19 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Butyrates: 2613
      - Aminobutyrates: 1253
        gamma-Aminobutyric Acid: 8890
        2-naphthylaminomethyl-gamma-aminobutyric acid: 19
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Aminobutyrates: 1253
    - gamma-Aminobutyric Acid: 8890
      - 2-naphthylaminomethyl-gamma-aminobutyric acid: 19

Experts

1.	Ahmed, Kazi Gias Uddin: 1 article (01/2021)
2.	Chen, Baofu: 1 article (01/2021)
3.	Chen, Haixiao: 1 article (01/2021)
4.	Chen, Hao: 1 article (01/2021)
5.	Chen, Shiyong: 1 article (01/2021)
6.	Chowdhury, Ahmed Hossain: 1 article (01/2021)
7.	Dong, Xuejun: 1 article (01/2021)
8.	Ge, Weigang: 1 article (01/2021)
9.	Guo, Tiannan: 1 article (01/2021)
10.	Hong, Luxiao: 1 article (01/2021)

Related Diseases

1.	Hypertension (High Blood Pressure) 01/01/2009 - "After adjusting for various confounders, hypertension and hypercholesterolemia were associated with a 144% (95% CI, 1.37-4.35) and 83% (95% CI, 1.13-2.94) higher likelihood of having diabetes, while moderate and vigorous exercise correlated with a 82% (95% CI, 0.09-0.81) and 67% (95% CI, 0.11-0.97) lower likelihood of diabetes. " 04/01/1989 - "In a randomized, double-blind crossover trial, indapamide (IND) 2.5 mg and hydrochlorothiazide 25 mg + amiloride 2.5 mg (HCTZ + A) were found to be equally effective in reducing blood pressure (BP) in 13 patients with moderate to severe hypertension already receiving chronic treatment with a beta blocker and a vasodilatator (supine BP during run-in: 169/103 +/- 21/5 mmHg; on IND: 149/91 +/- 21/14 mmHg; on HCTZ + A 144/88 +/- 23/5 mmHg). "
2.	Leukemia P388 02/01/1985 - "The nadir of peripheral white blood cell counts in mice with free drug, 6 mg/kg, was observed on Day 3 which was 50% of control, whereas with liposomal encapsulated drug it was reduced only 23% on Day 7. Doxorubicin in cardiolipin liposomes demonstrated enhanced chemotherapeutic potential against murine ascitic P388 leukemia with a 144% increased life span compared to 55% increased life span with free drug at a dose of 7.5 mg/kg on Days 1, 3, and 7. We conclude that doxorubicin liposomes developed in these studies possess improved therapeutic action as demonstrated by their ability to reduce the toxicity of the drug substantially."
3.	Birth Weight (Birth Weights) 12/01/2014 - "Maternal null GSTM1 was associated with a 144 g (95% CI, -291, 1) and combined maternal/infant null GSTT1 was associated with a 155 g (95% CI, -303, -8) decrease in birth weight. " 09/01/2008 - "Among women interviewed at 32 weeks gestation or later, multiple symptoms predicted a 144 g birth weight reduction compared with no symptoms. "
4.	COVID-19 01/01/2021 - "Here, we have recruited a 144 COVID-19 patient cohort, resulting in a data matrix containing 3,065 readings for 124 types of measurements over 52 days. " 01/01/2021 - "The prevalence of blood group A [144 (32.9%)] was significantly higher among COVID-19 patients than in the general population (p < 0.001). "
5.	Prion Diseases (Transmissible Spongiform Encephalopathies) 11/01/2005 - "Prion disease with a 144 base pair insertion: unusual cerebellar prion protein immunoreactivity."

Related Drugs and Biologics

1.	Liposomes (Liposome)
2.	Indapamide
3.	Hydrochlorothiazide (Esidrix)
4.	Doxorubicin (Adriamycin)
5.	Cardiolipins (Cardiolipin)
6.	Amiloride (Midamor)
7.	Prion Proteins
8.	Polyethylene (Polythene)
9.	Warfarin (Coumadin)
10.	Proteins (Proteins, Gene)