azelaic acid (Azelex)

RN given refers to parent cpd; structure

Also Known As:

Azelex; Finacea; nonanedioic acid; azelaic acid, dilithium salt; azelaic acid, dipotassium salt; azelaic acid, disodium salt; azelaic acid, monosodium salt; azelaic acid, potassium salt; azelaic acid, sodium salt; monosodium azelate; skinoren

Networked: 325 relevant articles (65 outcomes, 81 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - azelaic acid: 325

Experts

1.	Del Rosso, James Q: 14 articles (06/2017 - 01/2004)
2.	Draelos, Zoe Diana: 6 articles (04/2020 - 10/2004)
3.	Kircik, Leon H: 5 articles (06/2018 - 06/2011)
4.	Feldman, Steven R: 5 articles (10/2017 - 11/2005)
5.	Staedtler, Gerald: 5 articles (10/2016 - 06/2010)
6.	Fleischer, Alan B: 5 articles (11/2010 - 11/2003)
7.	Williamson, Todd: 4 articles (03/2020 - 05/2017)
8.	Elewski, Boni E: 4 articles (07/2015 - 11/2003)
9.	Graupe, Klaus: 4 articles (09/2010 - 06/2003)
10.	Thiboutot, Diane: 4 articles (01/2008 - 06/2003)

Related Diseases

1.	Rosacea (Acne Rosacea) 10/01/2008 - "Clinical studies have shown that azelaic acid 15% gel is an effective and safe first-line topical therapeutic option in patients with mild-to-moderate papulopustular rosacea. " 06/01/2008 - "Twice-daily azelaic acid (AzA) is the conventional regimen for papulopustular rosacea, but once-daily AzA may be equally effective, with greater convenience and dosing flexibility. " 02/01/2006 - "Azelaic acid (AzA) initially was released in a 20% cream formulation, which has been shown to be effective in the treatment of mild to moderate rosacea. " 06/01/2003 - "Efficacy and safety of azelaic acid (15%) gel as a new treatment for papulopustular rosacea: results from two vehicle-controlled, randomized phase III studies." 06/01/2004 - "Azelaic acid, a new treatment for rosacea."
2.	Acne Vulgaris 06/01/2017 - "A significant reduction in lesion counts was found throughout the study and the medication was well tolerated.</p> <p>CONCUSION: Azelaic acid 15% foam was effective in treating moderate truncal acne and facial acne in this pilot study. " 04/01/1989 - "Extensive multi-centre clinical trials have established that topical azelaic acid (a 20% cream) is an effective treatment for all types of acne. " 02/13/2018 - "Azelaic acid (AzA) and its derivatives have been known to be effective in the treatment of acne and various cutaneous hyperpigmentary disorders. " 10/01/1989 - "Azelaic acid is effective in the treatment of acne because it possesses an activity against all of these factors. " 06/01/2018 - "Azelaic acid 15% foam is effective and safe in the treatment of facial acne vulgaris. "
3.	Melanosis (Freckles) 10/01/2012 - "This study shows the efficacy of low-fluence QSNYL, topical 20% azelaic acid cream and their combination in melasma. " 09/01/2016 - "Comparison of efficacy of three dermocosmetic products, containing azelaic acid, in the reduction in melasma for women aged 35-55. " 09/01/2016 - "Comparison of efficacy of products containing azelaic acid in melasma treatment." 06/01/2022 - "The use of the liposomal form of azelaic acid provides an effective and well-tolerated addition to the treatment of melasma." 09/01/2016 - "Dermocosmetics containing azelaic acid significantly contribute to the clearing of melasma. "
4.	Erythema 05/01/2004 - "Azelaic acid 15% gel is a new first-tier topical agent proven effective in reducing inflammatory lesions and erythema. " 11/01/1999 - "Azelaic acid cream produced significantly greater mean reductions in total inflammatory lesions than did vehicle (azelaic acid: 73.4%; vehicle: 50.6%; (p = 0.011), and erythema severity score (azelaic acid: 47.9%; vehicle: 37.9%; (p = 0.031). " 01/01/2004 - "In all three studies, azelaic acid 15% gel recipients experienced continuous decreases in lesion counts and erythema throughout the 12- to 15-week treatment periods. " 01/01/2020 - "We have found that a DermaLab (Cortex Technologies, Hadsund, Denmark) chromameter measuring the erythema index of apple slice darkening appears to be able to differentiate the benefit of a formulation containing azelaic acid, a known skin-lightening ingredient, to minimize the darkening effects that occur in sliced apples. " 01/01/2009 - "Azelaic acid cream was significantly more effective on inflammatory lesions but not erythema than the other two creams. "
5.	Hutchinson's Melanotic Freckle (Lentigo Maligna) 11/01/1985 - "Azelaic acid was successfully used in the clinical treatment of 7 cases of lentigo maligna in that remission of the lesions was observed in all our patients. " 05/01/1993 - "Treatment of lentigo maligna with azelaic acid." 01/01/1989 - "The effect of azelaic acid is illustrated in a patient with lentigo maligna monitored clinically, histologically and ultrastructurally over the past 5 years." 01/01/1989 - "Topically applied azelaic acid led to complete clinical and histological resolution of lentigo maligna in more than 50 patients. " 01/01/1989 - "Ten years' experience of treating lentigo maligna with topical azelaic acid."

Related Drugs and Biologics

1.	hydroquinone (Esoterica)
2.	Metronidazole (Metric)
3.	glycolic acid (glycolate)
4.	Tretinoin (Retinoic Acid)
5.	Doxycycline (Periostat)
6.	Acids
7.	Adapalene (Differin)
8.	Sulfur
9.	Isotretinoin (Accutane)
10.	azelaic acid (Azelex)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Skin Care
4.	Solid-State Lasers
5.	Off-Label Use