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desmethylmisonidazole
Also Known As:
Ro 05-9963; demethylmisonidazole; 3-(2-nitro-I-imidazolyl)-1,2-propanediol
Networked:
10
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Nitro Compounds: 66
Nitroimidazoles: 565
Misonidazole: 539
desmethylmisonidazole: 10
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
Nitroimidazoles: 565
Misonidazole: 539
desmethylmisonidazole: 10
Related Diseases
1.
Pelvic Neoplasms
05/01/1984 - "
As part of a Phase I trial of hypoxic cell radiosensitizers, 19 women at Stanford University with advanced (n = 6) or recurrent (n = 13) pelvic neoplasms were treated with radiotherapy plus desmethylmisonidazole.
"
2.
Neoplasms (Cancer)
09/01/1984 - "
Some enhancement of CY was obtained with Ro 05-9963 and Ro 03-8799; however, the degree of enhancement varied according to tumor and acute or chronic sensitizer dose.
"
01/01/1983 - "
Comparison of the fate of misonidazole (RO 07-0582) and its metabolite desmethylmisonidazole (RO 05-9963), two hypoxic cell radiosensitizers: penetration properties in tumor bearing rats.
"
03/01/1982 - "
Desmethylmisonidazole was administered by continuous intraperitoneal infusion at a rate of 2.7 mg/gm body weight /24 hr. Tumor and serum drug levels were measured by high performance liquid chromatography.
"
02/01/1983 - "
These differences between the two routes of administration provide a rational basis for the expectation that a substantial increase of the therapeutic benefits of misonidazole and demethylmisonidazole in potentiating radiation therapy or chemotherapy can be expected in treating tumors confined to the i.p.
"
12/01/1982 - "
Examples of new developments in radiation oncology which may have eventual impact on large bowel cancer include: (1) high linear energy transfer deliverence techniques such as neutrons, heavy ions and pi-mesons; (2) radiation sensitizers such as misonidazole, desmethylmisonidazole and newer electronic affinic compounds; (3) radiation protectors such as WR-2727; and (4) new fractionation schedules.
"
3.
Sarcoma (Soft Tissue Sarcoma)
01/01/1983 - "
1. The hypoxic cell radiosensitizers misonidazole (RO 07-0582; Miso) and desmethylmisonidazole (RO 05-9963; Desmiso) were administered by the intraperitoneal route at a single dose of 250 mg/kg to Wistar rats bearing a chemo induced sarcoma.
"
4.
Peripheral Nervous System Diseases (PNS Diseases)
01/01/1984 - "
The radiation sensitizers misonidazole (MISO) and desmethylmisonidazole (DMM) can produce central and peripheral neuropathy in patients and laboratory animals.
"
5.
Fibrosarcoma
09/01/1984 - "
The abilities of misonidazole, Ro 05-9963, Ro 03-8799 and Sr-2508 to enhance the action of the drugs cyclophosphamide (CY) and melphalan (L-PAM) have been compared in two mouse fibrosarcomas at acute and chronic sensitizer doses.
"
Related Drugs and Biologics
1.
Misonidazole
2.
desmethylmisonidazole
3.
Radiation-Sensitizing Agents
4.
Metronidazole (Metric)
5.
Lactic Acid (Lactate)
6.
Etanidazole
7.
Niridazole
8.
Melphalan (Alkeran)
9.
Glucose (Dextrose)
10.
Cyclophosphamide (Cytoxan)
Related Therapies and Procedures
1.
Radiotherapy
2.
Parenteral Infusions
3.
Drug Therapy (Chemotherapy)
4.
Brachytherapy