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amopyroquine
RN given refers to parent cpd; structure
Also Known As:
PAM 780; amopyroquin; amopyroquine dihydrochloride; amopyroquine hydrochloride; 4-((7-chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-o-cresol
Networked:
10
relevant articles (
1
outcomes,
3
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinolines: 146
Aminoquinolines: 29
amopyroquine: 10
Related Diseases
1.
Malaria
06/01/1962 - "
Single dose treatment of human malaria by PAM-780: a study of its effects in P.
"
05/01/1993 - "
The efficacy of a 12-mg/kg (of body weight) intramuscular amopyroquin (ApQ) regimen (two successive 6-mg/kg injections at a 24-h interval), previously established from kinetic studies on healthy volunteers and multicenter studies on patients with malaria, was investigated in 152 patients (children and adults) in Gabon with Plasmodium falciparum malaria.
"
01/01/1994 - "
Finally, the emergence of severe adverse-effects after prolonged prophylaxis with amodiaquine and the lack of cross resistance of Plasmodium falciparum between chloroquine and amopyroquine, have led to a proposal for the use of intramuscular amopyroquine as an alternative for the treatment of chloroquine-resistant malaria.
"
2.
Body Weight (Weight, Body)
03/01/1989 - "
The disposition of amopyroquin was investigated in 10 healthy volunteers after a single 2-mg/kg (body weight) intramuscular dose of amopyroquin base.
"
04/01/1988 - "
The disposition of amopyroquin was studied in rats after a single 50-mg/kg (body weight) oral dose of amopyroquin base.
"
03/01/1989 - "
Twenty-two Plasmodium falciparum malaria patients were studied after treatment with one of the following regimens of intramuscularly injected amopyroquin base: 3 mg/kg (body weight), 6 mg/kg, or 6 mg/kg followed by 3 mg/kg 24 h later.
"
05/01/1993 - "
The efficacy of a 12-mg/kg (of body weight) intramuscular amopyroquin (ApQ) regimen (two successive 6-mg/kg injections at a 24-h interval), previously established from kinetic studies on healthy volunteers and multicenter studies on patients with malaria, was investigated in 152 patients (children and adults) in Gabon with Plasmodium falciparum malaria.
"
3.
Falciparum Malaria (Plasmodium falciparum Malaria)
05/01/1993 - "
Efficacy of intramuscular amopyroquin for treatment of Plasmodium falciparum malaria in the Gabon Republic.
"
03/01/1989 - "
Pharmacokinetics of intramuscular amopyroquin in healthy subjects and determination of a therapeutic regimen for Plasmodium falciparum malaria.
"
03/01/1989 - "
Twenty-two Plasmodium falciparum malaria patients were studied after treatment with one of the following regimens of intramuscularly injected amopyroquin base: 3 mg/kg (body weight), 6 mg/kg, or 6 mg/kg followed by 3 mg/kg 24 h later.
"
05/01/1993 - "
The efficacy of a 12-mg/kg (of body weight) intramuscular amopyroquin (ApQ) regimen (two successive 6-mg/kg injections at a 24-h interval), previously established from kinetic studies on healthy volunteers and multicenter studies on patients with malaria, was investigated in 152 patients (children and adults) in Gabon with Plasmodium falciparum malaria.
"
4.
Discoid Lupus Erythematosus
04/01/1964 - "
A TRIAL OF AMOPYROQUIN IN THE TREATMENT OF CHRONIC DISCOID LUPUS ERYTHEMATOSUS.
"
5.
Infections
05/01/1977 - "
The results showed that: (i) these 4-aminoquinolines were essentially equally active against infections with chloroquine-susceptible strains and (ii) the activities of amodiaquin, amopyroquin, and dichlorquinazine were reduced significantly in the face of chloroquine resistance, but (iii) well-tolerated doses of these compounds would cure infections with strains that fully resisted treatment with maximally tolerated doses of chloroquine.
"
05/01/1977 - "
This observation, confirmed in owl monkeys infected with this strain, led to a comparison of the activities of chloroquine, amodiaquin, amopyroquin, and dichlorquinazine (12,278 RP) against infections with various chloroquine-susceptible and chloroquine-resistant strains.
"
Related Drugs and Biologics
1.
Amodiaquine (Camoquin)
2.
Chloroquine (Aralen)
3.
Antimalarials (Antimalarial Agents)
4.
dichlorquinazine
5.
pyronaridine
Related Therapies and Procedures
1.
Injections
2.
Aftercare (After-Treatment)