amopyroquine

RN given refers to parent cpd; structure

Also Known As:

PAM 780; amopyroquin; amopyroquine dihydrochloride; amopyroquine hydrochloride; 4-((7-chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-o-cresol

Networked: 10 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Aminoquinolines: 29
        amopyroquine: 10

Related Diseases

1.	Malaria 06/01/1962 - "Single dose treatment of human malaria by PAM-780: a study of its effects in P. " 05/01/1993 - "The efficacy of a 12-mg/kg (of body weight) intramuscular amopyroquin (ApQ) regimen (two successive 6-mg/kg injections at a 24-h interval), previously established from kinetic studies on healthy volunteers and multicenter studies on patients with malaria, was investigated in 152 patients (children and adults) in Gabon with Plasmodium falciparum malaria. " 01/01/1994 - "Finally, the emergence of severe adverse-effects after prolonged prophylaxis with amodiaquine and the lack of cross resistance of Plasmodium falciparum between chloroquine and amopyroquine, have led to a proposal for the use of intramuscular amopyroquine as an alternative for the treatment of chloroquine-resistant malaria."
2.	Body Weight (Weight, Body) 03/01/1989 - "The disposition of amopyroquin was investigated in 10 healthy volunteers after a single 2-mg/kg (body weight) intramuscular dose of amopyroquin base. " 04/01/1988 - "The disposition of amopyroquin was studied in rats after a single 50-mg/kg (body weight) oral dose of amopyroquin base. " 03/01/1989 - "Twenty-two Plasmodium falciparum malaria patients were studied after treatment with one of the following regimens of intramuscularly injected amopyroquin base: 3 mg/kg (body weight), 6 mg/kg, or 6 mg/kg followed by 3 mg/kg 24 h later. " 05/01/1993 - "The efficacy of a 12-mg/kg (of body weight) intramuscular amopyroquin (ApQ) regimen (two successive 6-mg/kg injections at a 24-h interval), previously established from kinetic studies on healthy volunteers and multicenter studies on patients with malaria, was investigated in 152 patients (children and adults) in Gabon with Plasmodium falciparum malaria. "
3.	Falciparum Malaria (Plasmodium falciparum Malaria) 05/01/1993 - "Efficacy of intramuscular amopyroquin for treatment of Plasmodium falciparum malaria in the Gabon Republic." 03/01/1989 - "Pharmacokinetics of intramuscular amopyroquin in healthy subjects and determination of a therapeutic regimen for Plasmodium falciparum malaria." 03/01/1989 - "Twenty-two Plasmodium falciparum malaria patients were studied after treatment with one of the following regimens of intramuscularly injected amopyroquin base: 3 mg/kg (body weight), 6 mg/kg, or 6 mg/kg followed by 3 mg/kg 24 h later. " 05/01/1993 - "The efficacy of a 12-mg/kg (of body weight) intramuscular amopyroquin (ApQ) regimen (two successive 6-mg/kg injections at a 24-h interval), previously established from kinetic studies on healthy volunteers and multicenter studies on patients with malaria, was investigated in 152 patients (children and adults) in Gabon with Plasmodium falciparum malaria. "
4.	Discoid Lupus Erythematosus 04/01/1964 - "A TRIAL OF AMOPYROQUIN IN THE TREATMENT OF CHRONIC DISCOID LUPUS ERYTHEMATOSUS."
5.	Infections 05/01/1977 - "The results showed that: (i) these 4-aminoquinolines were essentially equally active against infections with chloroquine-susceptible strains and (ii) the activities of amodiaquin, amopyroquin, and dichlorquinazine were reduced significantly in the face of chloroquine resistance, but (iii) well-tolerated doses of these compounds would cure infections with strains that fully resisted treatment with maximally tolerated doses of chloroquine. " 05/01/1977 - "This observation, confirmed in owl monkeys infected with this strain, led to a comparison of the activities of chloroquine, amodiaquin, amopyroquin, and dichlorquinazine (12,278 RP) against infections with various chloroquine-susceptible and chloroquine-resistant strains. "

Related Drugs and Biologics

1.	Amodiaquine (Camoquin)
2.	Chloroquine (Aralen)
3.	Antimalarials (Antimalarial Agents)
4.	dichlorquinazine
5.	pyronaridine

Related Therapies and Procedures

1.	Injections
2.	Aftercare (After-Treatment)