tubulosine

01/01/2020 - "Tubulosine specifically decreased survival and proliferation of cancer cells, in which persistently active JAK3 is expressed, by inducing apoptotic and necrotic/autophagic cell death without affecting other oncogenic signalling. "
01/01/2019 - "The aim of this study was to investigate the novel functions of tubulosine in cancer treatment, specifically in breast cancer. "
09/01/1999 - "Alkaloids 1 and 3 showed weak cytotoxic activity against a panel of human cancer cell lines, with the potency of these compounds being markedly less than that of tubulosine (2)."
01/01/2019 - "These findings suggest that tubulosine may hold promise for the treatment of inflammation-associated cancers, including breast cancer."

01/01/2019 - "Tubulosine exhibits anticancer activity through functional inhibition of IL-6-induced JAK2/STAT3 signaling by targeting IL-6Rα/gp130 binding in breast cancer cells. "
01/01/2019 - "Tubulosine exhibited anticancer activity in IL-6-stimulated human breast cancer cells. "
01/01/2019 - "The aim of this study was to investigate the novel functions of tubulosine in cancer treatment, specifically in breast cancer. "
01/01/2019 - "Additionally, tubulosine suppressed IL-6-induced Janus kinase 2 (JAK2)/STAT3 signaling, resulting in decreased viability and induction of apoptotic cell death in breast cancer cells. "
01/01/2019 - "To investigate the activities of tubulosine, we performed molecular and cellular experiments such as Western blot and reverse transcription polymerase chain reaction analyses, immunoprecipitation and terminal deoxynucleotidyl transferase dUTP nick end labeling assays, and immunofluorescence staining using breast cancer cell lines. "

01/01/2019 - "These findings suggest that tubulosine may hold promise for the treatment of inflammation-associated cancers, including breast cancer."

09/01/1999 - "Bioassay-guided phytochemical investigation of the stems of Pogonopus speciosus, using human oral epidermoid carcinoma (KB) cells as a monitor, led to the isolation of a novel alkaloid, 1',2', 3',4'-tetradehydrotubulosine (1), along with tubulosine (2) and psychotrine (3) as bioactive constituents. "