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6- methyl- 1,2,3,5- tetrahydroimidazo(2,1- b)quinazolin- 2- one hydrochloride
Also Known As:
BL 3459; BL-3459; imidazo(2,1-b)quinazolin-2(3H)-one, 1,5-dihydro-6-methyl-, monohydrochloride
Networked:
3
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinazolines: 402
6-methyl-1,2,3,5-tetrahydroimidazo(2,1-b)quinazolin-2-one hydrochloride: 3
Related Diseases
1.
Shwartzman Phenomenon (Shwartzman Reaction)
10/01/1979 - "
In opposition to glucocorticoids and beside BL-3459 which interfere with other mechanisms involved in the phenomenon, the tested inhibitors of platelet aggregation were found incapable of preventing or reducing the severity of the Shwartzman reaction.
"
10/01/1979 - "
Several antiplatelet drugs (aspirin, sulfinpyrazone, hydroxychloroquine, dipyridamole, BL-3459, pyridinolcarbamate) were assayed for their ability to prevent the generalized Shwartzman reaction initiated by endotoxin in the pregnant rat, and compared to glucocorticoids (dexamethasone, hydrocortisone).
"
2.
Thrombosis (Thrombus)
08/01/1975 - "
While the precise mechanism of action of BL-3459 has not yet been determined, indications are that the compound may prove useful in the prevention of intravascular thrombosis.
"
08/01/1975 - "
BL-3459 inhibited elevation in screen filtration pressure induced by hemorrhage in dogs, endotoxemic death in rats, intravascular thrombosis produced by electrical stimulation of the carotid artery of the dog and thrombosis induced by means of a biolaser in the microvasculature of the rabbit ear chamber.
"
3.
Necrosis
11/01/1976 - "
The effect of a potent inhibitor of platelet aggregation, BL-3459, on adrenaline-induced myocardial necrosis was investigated in beagle dogs.
"
11/01/1976 - "
The effect of a potent inhibitor of platelet aggregation, BL-3459, on adrenaline-induced myocardial necrosis in beagle dogs.
"
4.
Hemorrhage
08/01/1975 - "
BL-3459 inhibited elevation in screen filtration pressure induced by hemorrhage in dogs, endotoxemic death in rats, intravascular thrombosis produced by electrical stimulation of the carotid artery of the dog and thrombosis induced by means of a biolaser in the microvasculature of the rabbit ear chamber.
"
Related Drugs and Biologics
1.
Glucocorticoids
2.
Sulfinpyrazone (Anturane)
3.
Pyridinolcarbamate (P23)
4.
Platelet Aggregation Inhibitors (Antiplatelet Drugs)
5.
Hydroxychloroquine (Plaquenil)
6.
Hydrocortisone (Cortisol)
7.
Epinephrine (Adrenaline)
8.
Endotoxins
9.
Dipyridamole (Persantine)
10.
Dexamethasone (Maxidex)