withaferin A

an antiestrogen and phytogenic antineoplastic agent isolated from leaves of Withania somnifera Dun.; structure

Also Known As:

5,6-epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dienoic acid delta-lactone; (4 beta,5 beta,6 beta,22R)-5,6-epoxy-4,22,27-trihydroxy-1-oxoergosta- 2,24-dien-26-oic acid, delta-lactone

Networked: 352 relevant articles (32 outcomes, 56 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Singh, Shivendra V: 27 articles (01/2021 - 01/2008)
2.	Hahm, Eun-Ryeong: 21 articles (01/2021 - 09/2008)
3.	Kakar, Sham S: 11 articles (01/2022 - 01/2012)
4.	Kim, Su-Hyeong: 10 articles (01/2021 - 08/2013)
5.	Lee, Joomin: 10 articles (11/2019 - 11/2010)
6.	Kaul, Sunil C: 9 articles (01/2022 - 09/2009)
7.	Wadhwa, Renu: 9 articles (01/2022 - 09/2009)
8.	Vanden Berghe, Wim: 9 articles (11/2021 - 10/2009)
9.	Kwon, Taeg Kyu: 9 articles (01/2015 - 12/2008)
10.	Cohen, Mark S: 9 articles (08/2014 - 09/2010)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2009 - "Withaferin A (WA) is an important withanolide holding promise in cancer treatment and as a relatively safe radiosensitive/chemotherapeutic agent, which is present in traces in all parts of Withania somnifera except the leaves, where as it is reported to be present in only two non-Indian chemotypes (South African chemotype/Israel chemotype 1). " 01/01/2023 - "Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms." 11/01/2021 - "Corrigendum to "Preparation and characterization of withaferin A loaded pegylated nanoliposomal formulation with high loading efficacy: In vitro and in vivo anti-tumor study" [Mater. " 03/01/2011 - "On the basis of this study we propose that in near future LXR-α agonist (Withaferin A) may definitely find its use in the therapeutic interventions directed towards the treatment of cancer." 02/15/2011 - "The study conducted here is an attempt to explore the potential of Withania somnifera's major constituent WA (Withaferin A) in attenuating the Hsp90/Cdc37 chaperone/co-chaperone interactions for enhanced tumor arresting activity and to elucidate the underlying mode of action using computational approaches. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2021 - "PREVENTION RELEVANCE: Withaferin A (WA) is highly effective in reducing burden and/or incidence of breast cancer in various preclinical models. " 01/01/2021 - "Withaferin A (WA), a small molecule derived from a medicinal plant (Withania somnifera), is highly effective in reducing burden and/or incidence of breast cancer in vivo in various preclinical models. " 10/01/2017 - "The present study revealed that withaferin-A (WA), the biologically active withanolide derived from Withania somnifera, initially induced formation of autophagosomes in human breast cancer cell-lines, MCF-7 and MDA-MB-231. " 01/01/2023 - "Withaferin A inhibits breast cancer-induced osteoclast differentiation." 01/01/2020 - "A Comprehensive Review and Perspective on Anticancer Mechanisms of Withaferin A in Breast Cancer."
3.	Fibrosis (Cirrhosis) 12/01/2020 - "We aimed to investigate whether withaferin A treatment ameliorates the development of renal fibrosis and its related mechanisms in a CKD mouse model. " 01/01/2023 - "Additionally, Withaferin A treatment significantly inhibited TGF-β-induced gene expression, which contributes to reduced hepatic fibrosis. " 01/01/2012 - "Our findings provide strong evidence that Withaferin-A could act as an anti-fibrotic compound against fibroproliferative diseases, including, but not limited to, cardiac interstitial fibrosis." 12/01/2020 - "Withaferin A protects against the CKD progression that is, at least in part, associated with the moderation of ER stress-related apoptosis, inflammation, and fibrosis in the kidneys of CKD. " 01/01/2015 - "Vimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin A In Vitro and during Corneal Fibrosis."
4.	Melanoma (Melanoma, Malignant) 11/12/2020 - "In this study, we evaluated the efficacy of Withaferin A (WFA), derived from the medicinal plant Withania Somnifera, as a novel therapeutic agent for the treatment of melanoma. " 03/01/2009 - "Effect of Withaferin A on the development and decay of thermotolerance in B16F1 melanoma: a preliminary study." 05/01/2000 - "Radiosensitization of a mouse melanoma by withaferin A: in vivo studies." 11/12/2020 - "Withaferin A activates TRIM16 for its anti-cancer activity in melanoma." 10/01/2011 - "Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2."
5.	Carcinogenesis 12/31/2018 - "Chemopreventive effects and associated mechanisms of withaferin A (WA) against intestinal and colon carcinogenesis remain unknown. " 03/04/2016 - "Accumulating data from different rodent models and cell culture experiments have revealed that withaferin-A suppresses experimentally induced carcinogenesis, largely by virtue of its potent anti-oxidative, anti-inflammatory, anti-proliferative and apoptosis-inducing properties. " 01/01/2010 - "Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis." 10/01/2009 - "Protective role of Withaferin-A on immunoexpression of p53 and bcl-2 in 7,12-dimethylbenz(a)anthracene-induced experimental oral carcinogenesis." 10/25/2008 - "Our results thus demonstrate the protective effect of Withaferin-A on red blood cell integrity during DMBA induced oral carcinogenesis."

Related Drugs and Biologics

1.	Lactones
2.	Ashwagandha
3.	withanone
4.	3- rhamnopyranosyl(1- 4)- glucopyranosyl- 12- diacetoxy- 20- hydroxywitha- 5,24- dienolide
5.	withanolide D
6.	Proteins (Proteins, Gene)
7.	Phytochemicals
8.	Withanolides
9.	anthracene
10.	Lipids

Related Therapies and Procedures

1.	Ayurvedic Medicine (Siddha Medicine)
2.	Therapeutics
3.	Chemoprevention
4.	Unani Medicine
5.	Transplantation