vindoline

major alkaloid from Vinca rosea L.; pentacyclic moiety in both vinblastin & vincristine; RN given refers to (2beta,3beta,4beta,5alpha,12beta,19alpha)-isomer; RN for cpd without isomeric designation not in Chemline 7/83

Also Known As:

vindoline, citrate, (2beta,3beta,4beta,5alpha,12beta,19alpha)-isomer; vindoline, monohydrochloride, (2beta,3beta,4beta,5alpha,12beta,19alpha)-isomer; (2 beta,3 beta,4 beta,5 alpha,12 beta,19 alpha)- 4-(acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy- 1-methylaspidospermidine-3-carboxylic acid

Networked: 19 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hazai, László: 2 articles (01/2022 - 10/2018)
2.	Keglevich, Péter: 2 articles (01/2022 - 10/2018)
3.	Szigetvári, Áron: 2 articles (01/2022 - 10/2018)
4.	Goboza, Mediline: 2 articles (08/2019 - 04/2019)
5.	Dékány, Miklós: 1 article (01/2022)
6.	Mayer, Szabolcs: 1 article (01/2022)
7.	Nagy, Nóra: 1 article (01/2022)
8.	Szántay Junior, Csaba: 1 article (01/2022)
9.	Dai, Min: 1 article (01/2021)
10.	Liu, Xuqiang: 1 article (01/2021)

Related Diseases

1.	Insulin Resistance 06/24/2023 - "These results demonstrated that vindoline has the potential to be used as a therapeutic agent to ameliorate obesity-induced T2DM-associated insulin resistance profile in adipocytes and skeletal muscles." 06/24/2023 - "Thus, in vitro studies of vindoline in insulin resistant skeleton muscle and dysfunctional adipocytes confirmed that vindoline treatment significantly mitigated insulin resistance in myotubes and improved functional status of adipocytes. " 06/24/2023 - "In this study, we investigated the effect of vindoline, an indole alkaloid of Catharanthus roseus on insulin resistance (IR), oxidative stress and inflammatory responses in dexamethasone (IR inducer)-induced dysfunctional 3T3-L1 adipocytes and high-glucose-induced insulin-resistant L6-myoblast cells. "
2.	Crohn Disease (Crohn's Disease) 11/01/2022 - "Vindoline ameliorates intestinal barrier damage in Crohn's disease mice through MAPK signaling pathway."
3.	Inflammation (Inflammations) 11/01/2022 - "Furthermore, Vindoline inhibited macrophage-mediated inflammation and protected against inflammation-induced intestinal barrier damage in the coculture system. " 11/01/2022 - "Bone-marrow-derived macrophages (BMDMs) and colonic organoids from mice were used to explore the inhibitory effect of Vindoline on macrophage-mediated inflammation and the protective effect on inflammation-induced intestinal barrier damage as well as the possible mechanism. " 08/13/2019 - "The aim of this study was to evaluate the effect of vindoline derived from Catharanthus roseus in diabetes-induced CVDs and kidney disease through assessing inflammation, oxidative stress, hyperlipidaemia and kidney function parameters. " 11/01/2022 - "In addition, Vindoline ameliorated colitis in CD mice by protecting against inflammation-induced intestinal barrier damage, which may be caused by inhibition of MAPK signaling pathway. " 11/01/2022 - "Il-10-deficient (Il-10-/- ) mice and wild-type (WT) mice (both aged 15 weeks, male) were used to explore the effect of Vindoline on colitis and intestinal barrier damage, as well as macrophage-mediated inflammation. "
4.	Type 2 Diabetes Mellitus (MODY) 04/01/2019 - "This present study evaluated the possible hepatoprotective effects of vindoline in a type 2 diabetes mellitus rat model. " 10/28/2013 - "Our findings suggested that vindoline might contribute to the anti-diabetic effects of Catharanthus roseus, and this natural product may find its more applications in the improvement of β-cell dysfunction and further the potential treatment of type 2 diabetes." 08/13/2019 - "Vindoline-A Natural Product from Catharanthus Roseus Reduces Hyperlipidemia and Renal Pathophysiology in Experimental Type 2 Diabetes." 04/01/2019 - "Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats."
5.	Kidney Diseases (Kidney Disease) 08/13/2019 - "The aim of this study was to evaluate the effect of vindoline derived from Catharanthus roseus in diabetes-induced CVDs and kidney disease through assessing inflammation, oxidative stress, hyperlipidaemia and kidney function parameters. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Indole Alkaloids
3.	Glucose (Dextrose)
4.	Dexamethasone (Maxidex)
5.	catharanthine
6.	Vincristine (Oncovin)
7.	Vinblastine (Vinblastine Sulfate)
8.	Alkaloids
9.	Secologanin Tryptamine Alkaloids (Alseroxylon)
10.	Paclitaxel (Taxol)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)