verruculogen

complex 6-O-methylindole cpd containing 3 nitrogens; induces tremor; tremorigenic metabolite from Penicillium verruculosum isolated from moldy peanuts; decreases GABA levels in CNS; structure

Also Known As:

(5R-(5 alpha,10 alpha,10a alpha,14a alpha,15b alpha))-1,10,10a,14,14a,15b-hexahydro-10,10a- dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-5H,12H-3,4-dioxa-5a,11a,15a-triaza cyclooct (1m) indeno (5,6-b)fluorene-11,15(2H,13H)- dione

Networked: 10 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - verruculogen: 10

Related Diseases

1.	Tremor (Tremors) 01/01/2023 - "Mechanistically, flies in which BomS6 is expressed in the nervous system exhibit an enhanced recovery from the tremors induced by injected verruculogen and display improved survival. " 01/01/1974 - "Pharmacological examination of verruculogen induced tremor." 09/01/1982 - "The nature and degree of tremor produced by the central vs peripheral routes suggest that the site of action of verruculogen is not immediately adjacent to the cannula sites in the brain. " 05/01/1982 - "[14C] Verruculogen (75 micrograms/kg) was given intravenously to a sheep under barbiturate anaesthesia to prevent the severe tremor and convulsions which would otherwise have occurred. " 01/01/1976 - "This finding substantiates our earlier suggestion that verruculogen-induced tremor is mediated by a loss of inhibitory GABA function."
2.	Peritonitis 01/01/1994 - "Besides spoilage, the heat-resistant molds produce a number of toxic secondary metabolites, such as byssotoxin A; byssochlamic acid; the carcinogen, patulin, the tremorgenic substances, fumitremorgin A and C, and verruculogen; fischerin, which caused fatal peritonitis in mice; and eupenifeldin, a compound possessing cytotoxicity as well as in vivo antitumor activity. "
3.	Ataxia (Dyssynergia) 01/01/1978 - "Verruculogen (V) and penitrem A (PA) represent a group of toxic secondary metabolites of mold contaminants of foodstuffs known as 'tremorgenic mycotoxins', which produce a unique neurotoxic syndrome characterized by sustained tremors, limb weakness, ataxia and convulsions. "

Related Drugs and Biologics

1.	Mycotoxins
2.	tremortin (penitrem A)
3.	Glutamic Acid (Glutamate)
4.	Neurotransmitter Agents (Neurotransmitter)
5.	Peroxides
6.	Patulin
7.	gamma-Aminobutyric Acid (GABA)
8.	Carcinogens
9.	Aspartic Acid (Aspartate)
10.	Amino Acids

Related Therapies and Procedures

1.	Cannula