tutin

neurotoxin found in Coriaria shrubs; hyenanchin is the hydroxy derivative; structure

Also Known As:

2a,3a-epoxy-3a,4a,5,6,7,7a-hexahydro-3a alpha,6 beta,7 beta-trihydroxy-5 alpha-isopropyl-7a alpha- methylspiro(indan-1,2'-oxirane) gamma-lactone; (1aS-(1a alpha,1b beta,2 beta,5 beta,6 alpha,6a beta,7 beta,7a alpha,8S*))-hexahydro-1b,6-dihydroxy- 6a-methyl-8-(1-methylethenyl)spiro(2,5-methano-7H- oxireno(3,4)cyclopent(1,2-d)oxepin-7,2'-oxiran)- 3(2 alpha H)-one

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Reeve, John: 2 articles (01/2018 - 10/2014)
2.	Cui, Jun: 1 article (05/2021)
3.	Li, Feifei: 1 article (05/2021)
4.	Li, Menglou: 1 article (05/2021)
5.	Shaheen, Tayyab: 1 article (05/2021)
6.	Tang, Guanghui: 1 article (05/2021)
7.	Wang, Tao: 1 article (05/2021)
8.	Woolfley, Tracy: 1 article (05/2021)
9.	Anderson, Philippa: 1 article (01/2018)
10.	Beasley, Michael: 1 article (01/2018)

Related Diseases

1.	Seizures (Absence Seizure) 10/01/2023 - "Together, these findings revealed that tutin caused epileptic seizures by activating CN. " 05/30/2006 - "A new rat model of acute seizures induced by tutin." 10/01/2023 - "Tutin, an established toxic natural product that causes epilepsy in rodents, is often used as a tool to develop animal model of acute epileptic seizures. " 10/01/2023 - "Our studies showed that calcineurin (CN) was a target of tutin, and that tutin activated CN, leading to seizures. " 10/01/2023 - "The toxic natural product tutin causes epileptic seizures in mice by activating calcineurin."
2.	Epilepsy (Aura) 10/01/2023 - "Our study fully explains the convulsive mechanism of tutin, which provides new ideas for epilepsy treatment and drug development." 10/01/2023 - "Tutin, an established toxic natural product that causes epilepsy in rodents, is often used as a tool to develop animal model of acute epileptic seizures. " 10/01/2023 - "In this study, for the first time, we conducted experiments to clarify the targets in tutin-induced epilepsy using thermal proteome profiling. " 10/01/2023 - "CN inhibitor and calcineurin A (CNA) knockdown experiments in vivo proved that tutin induced epilepsy by activating CN, and produced obvious nerve damage. "
3.	Body Weight (Weight, Body) 10/01/2014 - "To investigate the basis of this variability a pharmacokinetic study was undertaken in which 6 healthy males received a single oral dose of tutin-containing honey giving a tutin dose of 1.8 μg/kg body weight. "
4.	Poisoning 01/01/2018 - "Poisoning due to tutin in honey-a report of an outbreak in New Zealand." 05/01/2021 - "Tutin, a sesquiterpene lactone compound obtained from Coriaria sinica Maxim, a native Chinese poisonous plant, has antifeedant, absorption, and stomach poisoning against a variety of pests. "
5.	Weight Loss (Weight Reduction) 05/01/2021 - "Our results revealed that tutin exhibited significant antifeedant and insecticidal activities, paralysis, weight loss to M. "

Related Drugs and Biologics

1.	Proteome
2.	Calcineurin
3.	Sesquiterpenes
4.	Lactones
5.	Convulsants