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trimethyloxonium

active-site directed methylating agent; RN given refers to parent cpd

Also Known As:

trimethyloxonium hexachloroantimonate (-1); trimethyloxonium hexafluorophosphate (-1); Oxonium, trimethyl-

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Onium Compounds
  - trimethyloxonium: 1

Related Diseases

1.

Ganglion Cysts (Ganglion)

03/01/1982 - "1. A voltage clamp study was made of the K(+) permeability increases produced in certain identifiable neurones of the cerebral ganglion of Aplysia by any one of three distinct agonists (carbachol, histamine and dopamine).2. The three K(+) responses involve three distinct receptors, as shown by the selective effects of reversible antagonists (Gruol & Weinreich, 1979a) as well as by the differential, irreversible effects of trimethyloxonium (TMO) ions.3. Prolonged exposure of the neurones to one of the agonists reduces the response to the same agonist (desensitization) and, over the low concentration range, doubling the concentration of an agonist leads to supra-linear summation (potentiation).4. Prolonged exposure of the neurones to one of the agonists also reduces the response to the other agonists (cross-desensitization) and combined application of two agonists reveals cross-potentiation.5. "

Related Drugs and Biologics

1.	Ions
2.	Histamine (Histamine Dihydrochloride)
3.	Dopamine (Intropin)
4.	Carbachol (Carbastat)