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2-tolidine
RN given refers to parent cpd; structure
Also Known As:
2-tolidine dihydrochloride; 2-tolidine dihydrofluoride; 2-tolidine hexahydrofluoride; 2-tolidine perchlorate; 2-tolidine perchlorate (1-); 2-tolidine tetrahydrofluoride; 3,3'-dimethylbenzidine; o-tolidine; tolidine blue
Networked:
4
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Biphenyl Compounds: 7
Benzidines
2-tolidine: 4
Related Diseases
1.
Neoplasms (Cancer)
06/01/1991 - "
Conclusions: Under the conditions of these 14-month drinking water studies, there was clear evidence of carcinogenic activity of 3,3'-dimethylbenzidine dihydrochloride for male F344/N rats, as indicated by benign and malignant neoplasms of the skin, Zymbal's gland, preputial gland, liver, oral cavity, small and large intestine, lung, and mesothelium.
"
01/01/1989 - "
Neoplasms of preputial gland and skin were obtained from Fischer 344 male rats on lifetime drinking water studies of the benzidine congener 3,3'-dimethoxybenzidine, C.I. Direct Blue 15 or C.I. Acid Red 114, bisazobiphenyl dyes derived from 3,3'-dimethoxybenzidine and 3,3'-dimethylbenzidine.
"
2.
Carcinogenesis
06/01/1991 - "
Toxicology and carcinogenesis studies were conducted by administering 3,3'-dimethylbenzidine dihydrochloride (approximately 99% pure) in drinking water to groups of F344/N rats of each sex for 14 days, 13 weeks, or 9 or 14 months.
"
06/01/1991 - "
NTP Toxicology and Carcinogenesis Studies of 3,3'-Dimethylbenzidine Dihydrochloride (CAS No. 612-82-8) in F344/N Rats (Drinking Water Studies).
"
3.
Body Weight (Weight, Body)
06/01/1991 - "
Body Weights and Survival in the 14-Month Studies: The average amount of 3,3'-dimethylbenzidine dihydrochloride consumed per day was approximately 1.8, 4.0, or 11.2, mg/kg for low-, mid-, or high-dose male rats and 3.0, 6.9, or 12.9 mg/kg for low-, mid-, or high-dose female rats.
"
06/01/1991 - "
Based on the decreased survival, reductions in water consumption and body weight gain, and chemical-induced hepatocellular and renal lesions observed in the 13-week studies, the doses selected for the 9- and 14-month drinking water studies of 3,3'-dimethylbenzidine dihydrochloride were 0, 3 3,3'-dimethylbenzidine dihydrochloride were 0, 30, 70, and 150 ppm. Seventy rats of each sex were used in the control group, 45 in the low-dose group, 75 in the mid-dose group, and 70 in the high-dose group.
"
4.
Rhabdomyolysis
02/01/1985 - "
Evidence of rhabdomyolysis in both patients included dark, o-tolidine-positive urine, granular casts in the urinary sediment, and grossly increased activities of creatine kinase (greater than 60 000 U/L) in serum.
"
5.
Chromosome Aberrations (Chromosome Abnormalities)
06/01/1991 - "
3,3'-Dimethylbenzidine dihydrochloride induced sister-chromatid exchanges (CHO) and chromosomal aberrations in CHO cells in the absence of exogenous metabolic activation; these effects were not evident in test with S9 activation.
"
Related Drugs and Biologics
1.
Drinking Water
2.
Coloring Agents (Dyes)
3.
Dianisidine
4.
benzidine
5.
C.I. Acid Red 114
6.
direct blue 15
7.
2-Naphthylamine (2 Naphthylamine)
8.
Creatine Kinase (Creatine Phosphokinase)
9.
aniline (aniline hydrobromide)