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trimethylenediamine

RN given refers to parent cpd; structure

Also Known As:

1,3-diaminepropane; 1,3-diaminopropane; 1,3-propanediamine; trimethylenediamine dihydrochloride; trimethylenediamine hydrochloride

Networked: 30 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - trimethylenediamine: 30

Experts

1.	Chung, Bong Chul: 2 articles (02/2021 - 01/2008)
2.	Byun, Jeong Ah: 2 articles (01/2009 - 01/2008)
3.	Choi, Man Ho: 2 articles (01/2009 - 01/2008)
4.	Moon, Myeong Hee: 2 articles (01/2009 - 01/2008)
5.	Hong, Jongki: 1 article (02/2021)
6.	Lee, Ji Won: 1 article (02/2021)
7.	Lee, Yu Ra: 1 article (02/2021)
8.	Aoki, Dan: 1 article (01/2020)
9.	Favery, Bruno: 1 article (01/2020)
10.	Fukushima, Kazuhiko: 1 article (01/2020)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/18/2009 - "In pre-menopausal patients, the concentrations of 1,3-diaminopropane, N-acetyl putrescine (N-actPut), N-acetyl spermidine and spermidine (Sp) were higher (p<0.05) in pre-surgery breast cancer patients than in normal controls, with N-actPut (p<0.0005) and Sp (p<0.005) levels markedly increased. " 01/01/2008 - "However, 1,3-diaminopropane, putrescine, spermine and N-acetylspermidine levels in serum increased in breast cancer patients. " 04/01/2008 - "In this study, polyamine oxidase from maize (MPAO), which is involved in the terminal catabolism of spermidine and spermine to produce an aminoaldehyde, 1,3-diaminopropane and H(2)O(2), has been conditionally expressed at high levels in the nucleus of MCF-7 human breast cancer cells, with the aim to interfere with polyamine homeostasis and cell proliferation. " 02/21/2021 - "In our results, N-acetyl putrescine, N-acetyl spermidine, cadaverine, 1,3-diaminopropane, and epitestosterone were significantly higher in the breast cancer patient group. "
2.	Lymphoma (Lymphomas) 04/01/2023 - "This study is the first to describe the anti-inflammatory properties of betulinic acid, betulin, and its derivatives with amino acids 1,4-diaminebutane (Dab), 1,3-diaminepropane (Dap), Ornithine (Orn), and lysine (Lys) on murine macrophages from lymphoma site. "
3.	Neoplasms (Cancer) 04/25/2002 - "Preparation and characterization of platinum(II) and (IV) complexes of 1,3-diaminepropane and 1,4-diaminebutane: circumvention of cisplatin resistance and DNA interstrand cross-link formation in CH1cisR ovarian tumor cells." 07/13/1995 - "The effects of combined administration of vasoactive intestinal peptide (VIP) and the ornithine decarboxylase (ODC) inhibitor, 1,3-diaminopropane (DAP), on development of colon tumors induced by azoxymethane (AOM), on ODC activity of the colon wall, and on the labelling index of colon epithelial cells were investigated in inbred Wistar rats. " 01/21/1992 - "The effects of combined administration of bombesin and the ornithine decarboxylase (ODC) inhibitor 1,3-diaminopropane (DAP) on the incidence and number of gastric tumors induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), the ODC activity of the gastric wall and the labelling index of the gastric mucosa were investigated in inbred Wistar rats. " 08/15/1994 - "The effects of combined administration of bombesin (40 micrograms/kg body weight) and the ornithine decarboxylase (ODC) inhibitor, 1,3-diaminopropane (DAP), on the development of large and small intestinal tumors and the incidence of their metastasis to the peritoneum induced by azoxymethane (AOM, 7.4 mg/kg body weight), the ODC activity of the intestinal wall, and the labeling index of the intestinal mucosa and tumor were investigated in inbred Wistar rats. "
4.	Stomach Neoplasms (Stomach Cancer) 09/01/1995 - "The effects of combined administration of NaCl and the ornithine decarboxylase (ODC) inhibitor 1,3-diaminopropane (DAP) on the incidence and number of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and on the ODC activity of the gastric wall and the labeling index of the gastric mucosa were investigated in inbred Wistar rats. " 09/26/1997 - "The effects of combined administration of a catecholamine precursor, tyrosine methyl ester (TME), and an ornithine decarboxylase (ODC) inhibitor, 1,3-diaminopropane (DAP), on the incidence of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), the norepinephrine (NE) concentration and ODC activity of the gastric wall, and the labeling index of the gastric mucosa were investigated in inbred Wistar rats. " 02/15/1990 - "The effects of combined administration of tetragastrin and the ornithine decarboxylase inhibitor 1,3-diaminopropane (DAP) on the incidence and number of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and the BUdR labelling indices of the fundic and antral mucosae, were investigated in inbred Wistar rats. "
5.	Infections 01/01/2020 - "In addition to cadaverine, putrescine and 1,3-diaminopropane were also detected in root exudate by HPLC-MS/MS. Furthermore, exogenously applied cadaverine is sufficient to enhance M. incognita infection of Arabidopsis seedlings. " 01/01/2014 - "Following osmotic stress or pathogen infection, PA homeostasis was linked to enhanced activity of diamine oxidases (CuAO) and PA oxidases (PAO) and the production of 1,3-diaminopropane. " 01/01/1994 - "Of 5 diamines, 1,3-diaminopropane vaccine inhibited completely the infection, but hydrazine, ethylenediamine, putrescine, and cadaverine vaccines produced regional infection. "

Related Drugs and Biologics

1.	Spermidine
2.	Polyamines
3.	Spermine
4.	Ornithine
5.	Lysine (L-Lysine)
6.	Amino Acids
7.	Polyamine Oxidase
8.	Betulinic Acid
9.	betulin
10.	Ornithine Decarboxylase (Decarboxylase, Ornithine)