tetrandrine

a bisbenzylisoquinoline that exhibits antifibrogenic activity

Also Known As:

(+)-tetrandrine; (+-)-tetrandrine; (-)-tetrandrine; (R,S)-Tetrandrine; (S,S)-tetrandrine; 6,6',7,12-tetramethoxy-2,2'-dimethyl-(1beta)-berbaman; DL-tetrandrine; L-tetrandrine; NSC-77037; d-tetrandrine; hanjisong; isotetrandrine; isotetrandrine dihydrochloride; phaeanthine; tetrandrine dihydrochloride; tetrandrine dihydrochloride, (1beta)-isomer; tetrandrine, (1'beta)-isomer

Networked: 535 relevant articles (55 outcomes, 152 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Benzylisoquinolines: 151
    - tetrandrine: 535
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Benzylisoquinolines: 151
        tetrandrine: 535

Experts

1.	Hirano, Toshihiko: 11 articles (01/2021 - 11/2003)
2.	Li, Wenhua: 10 articles (12/2020 - 09/2011)
3.	Dai, Yue: 7 articles (01/2022 - 11/2015)
4.	Pei, Xiaohua: 7 articles (01/2020 - 08/2017)
5.	Chen, Yun: 7 articles (09/2011 - 02/2009)
6.	Tseng, Sheng-Hong: 7 articles (09/2011 - 02/2009)
7.	Li, Xue-Tao: 6 articles (06/2021 - 04/2016)
8.	Chung, Jing-Gung: 6 articles (04/2019 - 04/2016)
9.	Liu, Ting: 6 articles (06/2018 - 01/2015)
10.	Wei, Zhifeng: 5 articles (01/2022 - 02/2016)

Related Diseases

1.	Silicosis 09/01/1989 - "The genotoxicity of tetrandrine, a drug potentially useful for the treatment of silicosis, was studied using the micronucleus and the sister-chromatid exchange (SCE) assay systems. " 08/11/2023 - "The present study employed network pharmacology and molecular docking to determine the mechanism of action and the key active components of BYHWD of Tetrandrine in combination with BYHWD for silicosis. " 05/01/2022 - "Here, in this study, we established silicosis mouse models to investigate the effectiveness of tetrandrine of early and late therapeutic administration. " 12/01/1982 - "Studies of the chronic toxicity of tetrandrine in dogs: an inhibitor of silicosis." 08/11/2023 - "The potential targets for the treatment of silicosis using a combination of Tetrandrine and BYHWD were identified by considering the overlapping targets between compound drugs and silicosis. "
2.	Inflammation (Inflammations) 01/01/2022 - "In conclusion, tetrandrine has good efficacy in treating RA by regulating neutrophil-involved inflammation and NET formation." 09/01/2021 - "Collectively, findings in this study demonstrated that tetrandrine ameliorates AD by suppressing microglia-mediated inflammation and neurotoxicity." 11/01/2023 - "Tetrandrine improved the survival rate of random flaps by promoting angiogenesis, inhibiting apoptosis, and reducing inflammation in the flap tissue through the modulation of the PI3K/AKT signaling pathway." 04/01/2014 - "The present study aimed to reveal the protective effect of isotetrandrine (ITD), a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. " 11/01/2023 - "Additionally, tetrandrine decreased the expression of Bax, which is associated with the induction of apoptosis, and also decreased inflammation in the flap tissue. "
3.	Neoplasms (Cancer) 01/01/2023 - "Here, we aimed to evaluate the efficacy of tetrandrine in cancer stemness and epithelial to mesenchymal transition (EMT) in TNBC, and to explore the underlying mechanisms. " 08/01/2020 - "Studies have demonstrated that tetrandrine reverses multidrug resistance (MDR) in animal models or cell lines derived from multiple cancer types. " 01/01/2018 - "In this study, we show for the first time that tetrandrine (TET) inhibits proliferation of the PaCa cells and inhibits PaCa tumor growth. " 01/01/2018 - "The study in vivo also showed that the maximum non-cytotoxic dose of tetrandrine could reduce tumor growth in xenograft tumor model. " 01/01/2018 - "It has also been discussed that how tetrandrine potentiate anticancer effect in different types of cancers by modulating multidrug resistance under in vitro and in vivo trials including the available literature on the clinical trials."
4.	Fibrosis (Cirrhosis) 04/01/2004 - "In the present study, we examined the apoptosis-inducing effect of tetrandrine on activated hepatic stellate cells, as the therapeutic goal in hepatic fibrosis is to eliminate the activated hepatic stellate cells by apoptosis. " 01/01/2021 - "Our data suggest that protective effect of tetrandrine against lung fibrosis might be through promoting Rheb-mTOR and NRF2-SQSTM1 mediated autophagy. " 06/15/2015 - "Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis." 02/01/2010 - "Tetrandrine also inhibited fibrosis and attenuated the inflammatory response. " 01/01/2007 - "Tetrandrine exerts antifibrotic effects in both HSC-T6 cells and in rats with DMN-induced fibrosis."
5.	Hypertension (High Blood Pressure) 12/15/2016 - "As a multi-targets drug, tetrandrine might be favorable to the hypertension patients who suffered poor sleep." 02/01/1991 - "[Hypertension treated with isotetrandrine]." 12/22/2008 - "Tetrandrine (TET) is the major pharmacologically active compound of Chinese herb Stephania tetrandra S Moore, which has been used traditionally for the treatment of rheumatic disorders, silicosis and hypertension. " 01/01/2014 - "This is the first observation that tetrandrine possesses both anti-hypertension and hypnotic effects in SHR and suggested that tetrandrine may be useful for the treatment of hypertension patients who accompanied with short sleep time and poor sleep efficiency." 12/15/2016 - "In the previous study, tetrandrine revealed both anti-hypertension and hypnotic effects in spontaneously hypertensive rats (SHRs). "

Related Drugs and Biologics

1.	Alkaloids
2.	Liposomes (Liposome)
3.	Tablets
4.	Benzylisoquinolines
5.	Acetylcysteine (Siran)
6.	Isoproterenol (Isoprenaline)
7.	Calcium Channel Blockers (Blockers, Calcium Channel)
8.	nitrofen
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	Citric Acid (Citrate)

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Drug Therapy (Chemotherapy)
4.	Oral Administration
5.	Chemoprevention