tetrahydro-11-deoxycortisol

(3alpha,5beta)-isomer has angiostatic activity

Also Known As:

3 alpha, 17,21-trihydroxy-5 beta-pregnan-20-one; 3alpha,5beta-THS; 5 beta-pregnane-3alpha,17alpha,21-triol-20-one; tetrahydro compound S; tetrahydro-Reichstein's substance S; tetrahydrodeoxycortisol; trihydroxypregnanone; pregnan-20-one, 3,17,21-trihydroxy-, (3 alpha,5 beta)-

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Malevanaya, E V: 1 article (09/2019)
2.	Shafigullina, Z R: 1 article (09/2019)
3.	Velikanova, L I: 1 article (09/2019)
4.	Vorokhobina, N V: 1 article (09/2019)
5.	Avula, Aditya V: 1 article (12/2017)
6.	Bancos, Cristian: 1 article (12/2017)
7.	Bancos, Irina: 1 article (12/2017)
8.	Grebe, Stefan K: 1 article (12/2017)
9.	Hines, Jolaine M: 1 article (12/2017)
10.	Singh, Raman D: 1 article (12/2017)

Related Diseases

1.	Adrenocortical Carcinoma 06/01/1954 - "Isolation of pregnane-3-alpha, 17-alpha, 21-triol-20-one (tetrahydro compound S) from the urine of a woman with metastatic adrenocortical carcinoma." 12/01/2009 - "Three abnormal patterns of urinary steroid excretion were identified in patients with adrenocortical carcinoma at presentation and/or follow-up of residual disease: (1) hypersecretion in multiple steroid axes; (2) excretion of unusual metabolites, notably 5-pregnene-3alpha,16alpha,20alpha-triol, 5-pregnene-3beta,16alpha,20alpha-triol, and neonatal steroid metabolites in the post-neonatal period; (3) increase of tetrahydro-11-deoxycortisol relative to total cortisol metabolites. " 12/01/2017 - "Compared with patients with adrenocortical adenoma (ACA), patients with adrenocortical carcinoma (ACC) had 11 steroids with increased Z scores, especially tetrahydro-11-deoxycortisol (14 vs 0.5, P < 0.001), pregnanetriol (7.5 vs -0.4, P = 0.001), and 5-pregnenetriol (5.4 vs -0.4, P = 0.01). "
2.	Adrenocortical Adenoma (Disease, Conn's) 12/01/2017 - "Compared with patients with adrenocortical adenoma (ACA), patients with adrenocortical carcinoma (ACC) had 11 steroids with increased Z scores, especially tetrahydro-11-deoxycortisol (14 vs 0.5, P < 0.001), pregnanetriol (7.5 vs -0.4, P = 0.001), and 5-pregnenetriol (5.4 vs -0.4, P = 0.01). "
3.	Sinusitis 11/01/1990 - "In the case of serous, purulent and purulent-polypous sinusitis there was a slight correlation for the coefficients of norepinephrine + cortisol, epinephrine + cortisol, epinephrine + tetrahydrodeoxycortisol."
4.	Neoplasms (Cancer) 03/15/2023 - "After examining different models, a decision tree using excretions of only 5-pregnenetriol and tetrahydro-11-deoxycortisol classified three groups with low, intermediate, and high risk for malignancy. "
5.	Pituitary Dwarfism 02/01/1982 - "Transient impairment or delay of urinary trihydroxypregnanone (THS) response to metyrapone in boys with delayed adolescence and in patients with isolated growth hormone deficiency."

Related Drugs and Biologics

1.	Steroids
2.	Hydrocortisone (Cortisol)
3.	Cortodoxone (11 Deoxycortisol)
4.	Pregnanetriol
5.	Norepinephrine (Noradrenaline)
6.	Metyrapone
7.	Epinephrine (Adrenaline)
8.	Desoxycorticosterone (Deoxycorticosterone)
9.	Adrenocorticotropic Hormone (ACTH)