2,5,2',5'-tetrachlorobiphenyl

Also Known As:

2,2',5,5'-tetrachlorobiphenyl; PCB 52

Networked: 8 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        Polychlorinated Biphenyls: 1778
        2,5,2',5'-tetrachlorobiphenyl: 8
  - Halogenated Hydrocarbons: 42
    - Chlorinated Hydrocarbons: 240
      - Polychlorinated Biphenyls: 1778
        2,5,2',5'-tetrachlorobiphenyl: 8
- Dioxins and Dioxin-like Compounds: 5
  - Polychlorinated Biphenyls: 1778
    - 2,5,2',5'-tetrachlorobiphenyl: 8

Experts

1.	Chen, Dar-Ren: 1 article (07/2009)
2.	Chen, Shou-Tung: 1 article (07/2009)
3.	Chuang, Ming-Chieh: 1 article (07/2009)
4.	Huang, Ching-Lung: 1 article (07/2009)
5.	Lin, Chia-Hua: 1 article (07/2009)
6.	Lin, Po-Hsiung: 1 article (07/2009)
7.	Wang, Ying-Jan: 1 article (07/2009)
8.	Eriksson, Per: 1 article (12/2006)
9.	Fischer, Celia: 1 article (12/2006)
10.	Fredriksson, Anders: 1 article (12/2006)

Related Diseases

1.	Body Weight (Weight, Body) 09/01/2023 - "PCB 52 exposure did not affect overall body weight. " 08/09/2023 - "PCB 52 exposure did not affect overall body weight. " 12/01/2006 - "In the present study, 10-day-old Naval Medical Research Institute male mice were given one single oral dose of PCB 52 (1.4 micromol/kg body weight [bw]) + PBDE 99 (1.4 micromol), PCB 52 (1.4 micromol or 14 micromol), or PBDE 99 (1.4 micromol or 14 micromol). " 05/15/1996 - "Neonatal exposure of male NMRI mice on postnatal day 10 to 2,2',5,5'-tetrachlorobiphenyl (4.1 mg/kg body weight, per os) was shown to alter the response to a cholinergic agent, nicotine, at an adult age of 4 months, but not to d-amphetamine, an agent known to affect the dopaminergic system." 05/15/1996 - "The objective of the present study was to investigate whether neonatal exposure to single PCB (polychlorinated biphenyl) congeners 2,4,4'-trichlorobiphenyl (IUPAC 28), 2,2',5,5'-tetrachlorobiphenyl (IUPAC 52), 2,3',4,4',5-pentachlorobiphenyl (IUPAC 118) and 2,3,3',4,4',5-hexachlorobiphenyl (IUPAC 156) when given as one single dose (0.7-14 μmol/kg body weight per os) to 10-day-old male NMRI mice could induce persistent neurotoxic effects in the adult animal. "
2.	Breast Neoplasms (Breast Cancer) 07/10/2009 - "The goal of this study was to examine the potential of lower chlorinated PCBs, including 2,2',5,5'-tetrachlorobiphenyl (PCB52) and 3,3',4,4'-tetrachlorobiphenyl (PCB77), to induce DNA damage and apoptosis in human MDA-MB-231 (MDA) and MCF-7 breast cancer cells. "
3.	Papilloma (Papillomatosis) 03/01/1985 - "Sensitive assays for the induction of lung adenomas in A/J mice or skin papillomas in SENCAR mice failed to show activity for either 2,2',5,5'-tetrachlorobiphenyl or 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide. "
4.	Neoplasms (Cancer) 03/01/1985 - "The activities of 2,2',5,5'-tetrachlorobiphenyl, its 3,4-oxide metabolite, and 2,2',4,4'-tetrachlorobiphenyl in tumor induction and promotion assays."
5.	Hepatocellular Carcinoma (Hepatoma) 12/07/1995 - "In the recombinant Hepa1c1c7 mouse hepatoma (H1L1.1c7) cells strong antagonistic interaction of 2,2',5,5'-tetrachlorobiphenyl (PCB52) with luciferase expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3,3',4,4'-tetrachlorobiphenyl (PCB77) was observed, and similarly, between 2,2',3,3',4,4'-hexachlorobiphenyl (PCB128) and PCB77. "

Related Drugs and Biologics

1.	Polychlorinated Biphenyls (PCBs)
2.	3,4,3',4'-tetrachlorobiphenyl
3.	2,3,3',4,4',5-hexachlorobiphenyl
4.	pentabromodiphenyl ether (PBDE)
5.	2,4,4'-trichlorobiphenyl
6.	2,3',4,4',5-pentachlorobiphenyl
7.	Cholinergic Agents (Cholinergics)
8.	Nicotine
9.	Luciferases
10.	Dextroamphetamine (Dexedrine)