skyrin

main pigment of toxin rice fungus Penicillium islandicum; RN given refers to parent cpd; structure

Also Known As:

2,2',4,4',5,5'-Hexahydroxy-7,7'-dimethyl-1,1'-bianthracene-9,9',10,10'-tetrone; 2,2',4,4',5,5'-hexahydroxy-7,7'-dimethyl-1,1'-bisanthraquinone; skyrin, (+)-isomer; skyrin, (+-)-isomer

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Anthracenes: 12
        Anthrones: 12
        Anthraquinones: 788
        skyrin: 6
- Quinones: 434
  - Anthraquinones: 788
    - skyrin: 6
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Anthracenes: 12
    - Anthrones: 12
      - Anthraquinones: 788
        skyrin: 6

Experts

1.	Gálová, Eliška: 1 article (05/2022)
2.	Horváthová, Eva: 1 article (05/2022)
3.	Kyzek, Stanislav: 1 article (05/2022)
4.	Túryová, Eva: 1 article (05/2022)
5.	Zajičková, Terézia: 1 article (05/2022)
6.	Ševčovičová, Andrea: 1 article (05/2022)
7.	Šályová, Eva: 1 article (05/2022)
8.	Babinčák, Marián: 1 article (04/2021)
9.	Fedoročko, Peter: 1 article (04/2021)
10.	Jendželovský, Rastislav: 1 article (04/2021)

Related Diseases

1.	Neoplasms (Cancer) 09/10/2017 - "Linking secondary metabolites to biosynthesis genes in the fungal endophyte Cyanodermella asteris: The anti-cancer bisanthraquinone skyrin." 03/01/2016 - "Dicatenarin and skyrin showed marked growth inhibition against the NCI60/ATCC panel of human cancer cell lines with least IC50 values of 12 µg/mL and 27 µg/mL, respectively, against the human pancreatic cancer (MIA PaCa-2) cell line. " 05/10/2022 - "These skyrin effects were analyzed by cell-free methods, and cytotoxicity was estimated by an MTT assay and by a trypan blue exclusion test, while the genotoxic/antigenotoxic potential was examined by comet assay using non-cancerous human lymphocytes and the HepG2 cancer cell line. " 01/01/2016 - "In this study, skyrin, a dianthraquinone compound with smaller and distorted π-cores and thus decreased aggregates as compared with hypericin (Hyp), was designed to target necrosis for tumor therapy. "
2.	Necrosis 01/01/2016 - "In this study, skyrin, a dianthraquinone compound with smaller and distorted π-cores and thus decreased aggregates as compared with hypericin (Hyp), was designed to target necrosis for tumor therapy. "
3.	Colorectal Neoplasms (Colorectal Cancer) 04/01/2021 - "Death Receptor 5 (TNFRSF10B) Is Upregulated and TRAIL Resistance Is Reversed in Hypoxia and Normoxia in Colorectal Cancer Cell Lines after Treatment with Skyrin, the Active Metabolite of Hypericum spp."
4.	Pancreatic Neoplasms (Pancreatic Cancer) 03/01/2016 - "Dicatenarin and skyrin showed marked growth inhibition against the NCI60/ATCC panel of human cancer cell lines with least IC50 values of 12 µg/mL and 27 µg/mL, respectively, against the human pancreatic cancer (MIA PaCa-2) cell line. " 03/01/2016 - "Our data indicated that dicatenarin and skyrin induce reactive oxygen species-mediated mitochondrial permeability transition and resulted in an increased induction of caspase-3 apoptotic proteins in human pancreatic cancer (MIA PaCa-2) cells. "
5.	Leukemia L1210 02/01/1984 - "The anthraquinone mycotoxins emodin and skyrin were examined for the inhibitory effects on murine leukemia L1210 culture cells, oxidative phosphorylation of rat liver mitochondria, and Na+, K+-activated ATPase activity of rat brain microsomes to find the differences between their modes of toxic action. "

Related Drugs and Biologics

1.	hypericin
2.	TNF-Related Apoptosis-Inducing Ligand Receptors
3.	Caspase 3 (Caspase-3)
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Trypan Blue
6.	Proteins (Proteins, Gene)
7.	Mycotoxins
8.	Toxic Actions
9.	Emodin (Archin)
10.	Anthraquinones

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)