sempervirine

10/28/2020 - "We found that sempervirine not only affects cell growth of p53-wt cancer cells, but it is also active in p53-mutated and p53-null cells by triggering p53-dependent and independent pathways without affecting non-transformed cells. "
01/01/2021 - "Furthermore, sempervirine inhibited HCC tumor growth and enhances the anti-tumor effect of sorafenib in vivo. "
10/28/2020 - "Sempervirine inhibits RNA polymerase I transcription independently from p53 in tumor cells."
01/01/2021 - "The potential antitumor effects of sempervirine (SPV), an alkaloid compound derived from the traditional Chinese medicine Gelsemium elegans Benth., on different malignant tumors were described in detail. "
10/28/2020 - "In the search of small molecules that can target MDM2/p53 pathway in testicular germ cell tumors (TGCTs), we identified sempervirine (2,3,4,13-tetrahydro-1H-benz[g]indolo[2,3-a]quinolizin-6-ium), an alkaloid of Gelsemium sempervirens, that has been previously proposed as an inhibitor of MDM2 that targets p53-wildtype (wt) tumor cells. "

11/18/1956 - "[Cardiac syncope induced by adrenalin and sempervirine]."

10/28/2020 - "In the search of small molecules that can target MDM2/p53 pathway in testicular germ cell tumors (TGCTs), we identified sempervirine (2,3,4,13-tetrahydro-1H-benz[g]indolo[2,3-a]quinolizin-6-ium), an alkaloid of Gelsemium sempervirens, that has been previously proposed as an inhibitor of MDM2 that targets p53-wildtype (wt) tumor cells. "

01/01/1986 - "Alstonine, serpentine and sempervirine, when used at appropriate concentrations cure a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells, as well as Swiss mice bearing Ehrlich ascites carcinoma cells. "

01/01/2021 - "Sempervirine Inhibits Proliferation and Promotes Apoptosis by Regulating Wnt/β-Catenin Pathway in Human Hepatocellular Carcinoma."