saikogenin A

RN given refers to (3beta,4alpha,16beta)-isomer; structure

Also Known As:

saikogenin A, (3beta,4alpha,16alpha)-isomer; saikogenin D; (3 beta,4 alpha,16 beta)-oleana-11,13(18)-diene-3,16,23,28-tetrol

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

1.	Kodama, Yasuo: 2 articles (06/2006 - 08/2003)
2.	Nakahata, Norimichi: 2 articles (06/2006 - 08/2003)
3.	Ohizumi, Yasushi: 2 articles (06/2006 - 08/2003)
4.	Yoshida, Makoto: 2 articles (06/2006 - 08/2003)
5.	Lv, Xiaochuan: 1 article (06/2006)
6.	Toriniwa, Yasufumi: 1 article (06/2006)
7.	Tsuchiya, Chikako: 1 article (08/2003)
8.	Xiaochuan, Lv: 1 article (08/2003)

1.	Edema (Dropsy) 08/01/1986 - "Saikogenin A was less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. "
2.	Glioma (Gliomas) 06/01/2006 - "We examined the effect of saikogenin D on arachidonic acid metabolism in C6 rat glioma cells to clarify its anti-inflammatory mechanism. " 08/01/2003 - "To clarify the pharmacological profile of saikogenin D, we examined the effect of saikogenin D on prostaglandin E2 (PGE2) production and intracellular free Ca2+ concentration ([Ca2+]i) in C6 rat glioma cells. " 08/01/2003 - "Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells."
3.	Pseudomonas Infections 01/01/1990 - "Protective effect of saikosaponin A, saikosaponin D and saikogenin D against Pseudomonas aeruginosa infection in mice."
4.	Inflammation (Inflammations) 08/01/1986 - "These results suggest that the anti-inflammatory action of saikogenin A are due to an increase in corticosterone caused by the release of ACTH and a direct effect on the process of inflammation." 08/01/1986 - "Otherwise, the direct action of saikogenin A on the process of inflammation cannot be ruled out because saikogenin A also functioned in the adrenalectomized rats and it inhibited the release of histamine induced by compound 48/80. "

1.	Carrageenan
2.	Arachidonic Acid (Vitamin F)
3.	Dinoprostone (PGE2)
4.	Histamine (Histamine Dihydrochloride)
5.	Corticosterone
6.	p-Methoxy-N-methylphenethylamine
7.	Adrenocorticotropic Hormone (ACTH)
8.	saikosaponin D