rhodioloside

01/01/2018 - "The prophylactic efficacy of Salidroside for amelioration of global hypoxia induced neuronal aging was studied in adult male Sprague-Dawley rats exposed to hypobaric hypoxia simulating an altitude of 7600 m for 21 days. "
06/01/2021 - "The metabolomics and bioinformatics methods were used to explore the protective effects of salidroside under hypoxia condition. "
06/01/2020 - "The objective was to investigate the anti-inflammatory effects of salidroside through the PI3K/Akt signaling pathway and its protective effects on acute hypoxia-induced myocardial injury in rats. "
03/01/2020 - "MicroRNA-21 mediates the protective effects of salidroside against hypoxia/reoxygenation-induced myocardial oxidative stress and inflammatory response."
01/01/2020 - "Taken together, our findings revealed that salidroside exerts protective effects against hypoxia induced liver injury through inhibiting ER stress mediated apoptosis via IRE1α/JNK pathway."

01/15/2020 - "Our findings suggest that salidroside ameliorates AGEs-induced endothelial inflammation and oxidative stress, partially via the AMPK/NF-κB/NLRP3 signaling pathway."
12/01/2023 - "Salidroside treatment relieved I/R-induced inhibitory effect on AC16 cell proliferation and promoting effects on cell apoptosis, inflammation, and oxidative stress. "
02/01/2023 - "Clearance of the gut flora blocked the benefit of salidroside on colonic inflammation and Th17/Treg adaptive immunity, but transplanting salidroside-treated foecal bacterium into flora-depleted wild mice reproduced the resistance of salidroside to gut inflammation. "
01/15/2020 - "Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs."
01/01/2023 - "In conclusion, the salidroside analogs (2 and 3) showed promising therapeutical effect on septic myocardial injury in LPS-model rats, and they could be good candidates for clinical trials against inflammation and septic myocardial injury."

07/01/2021 - "Salidroside treatment not only improved erectile function in rats with BCNI, but also inhibited apoptosis and fibrosis and ameliorated the loss of nerve content and endothelial and corpus cavernosum smooth muscle cells by promoting protective autophagy."
03/04/2019 - "Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways."
08/01/2010 - "The present study aimed to investigate the mechanism of hepatic differentiation of rMSCs in vitro and synergistic effects of rMSCs and salidroside on the experimental hepatic fibrosis in rats. "
10/15/2023 - "Salidroside (SAL) has been proved to have a certain effect on anti-fibrosis in various organs. "
10/15/2023 - "Integrating network pharmacology and experimental verification to explore the mechanisms of salidroside against myocardial fibrosis."

02/01/2023 - "Additionally, the antiferroptotic effects of salidroside against lung ischemia-reperfusion injury were eliminated in Nrf2-/- mice. "
02/01/2023 - "This study clearly shows that salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis."
01/01/2022 - "The purpose of this study was to examine the effect of salidroside on testicular ischemia-reperfusion injury. "
04/01/2023 - "Corrigendum to "Salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis" [Int. "
02/01/2023 - "Furthermore, ferroptotic cells recruited macrophages via CCL2, whereas salidroside lowered CCL2 expression and inhibited ferroptosis-induced macrophage chemotaxis in lung ischemia-reperfusion injury. "

05/01/2013 - "The present study aimed to investigate the protective effects of salidroside on Aβ-induced cognitive impairment in vivo. "
11/01/2020 - "Our study showed that salidroside treatment suppressed the kindling acquisition process, ameliorated cognitive impairment, and rescued the number of pyramidal neurons in the CA3 regions. "
01/01/2019 - "The objective of the present study was to investigate the protective effect of salidroside on diabetes and diabetes‑induced cognitive impairment. "
09/01/2023 - "Salidroside exerts neuroprotective properties in diabetic cognitive dysfunction partly via activating the PI3K/Akt/GSK-3β signaling pathway."
06/01/2023 - "Salidroside alleviates cognitive impairment and inhibits neuronal ferroptosis. "