cyclonite (RDX)

explosive & convulsant; structure

Also Known As:

RDX; Hexogen; cyclotrimethylene trinitramine; 1,3,5-trinitro-1,3,5-triazacyclohexane; 1,3,5-trinitro-1,3,5-triazine; cyclotrimethylenetrinitramine; hexahydro-1,3,5-trinitro-1,3,5-triazine; hexahydro-1,3,5-trinitro-s-triazine

Networked: 122 relevant articles (2 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Triazines: 306
    - cyclonite: 122

Experts

1.	Perkins, Edward J: 7 articles (01/2014 - 07/2007)
2.	Gust, Kurt A: 6 articles (04/2015 - 07/2007)
3.	Dreger, Zbigniew A: 6 articles (10/2012 - 09/2007)
4.	Gupta, Yogendra M: 6 articles (10/2012 - 09/2007)
5.	Johnson, Mark S: 5 articles (02/2012 - 02/2003)
6.	Reddy, Gunda: 4 articles (02/2012 - 11/2005)
7.	Meyer, Sharon A: 3 articles (01/2017 - 09/2005)
8.	Guan, Xin: 3 articles (01/2014 - 07/2009)
9.	Wilbanks, Mitchell S: 3 articles (02/2013 - 01/2011)
10.	Habib, Tanwir: 3 articles (07/2012 - 01/2011)

Related Diseases

1.	Seizures (Absence Seizure) 05/01/2011 - "Studies investigating the mechanism of toxicity of RDX have shown that it affects the central nervous system causing seizures in humans and animals. " 10/01/2023 - "Cyclonite-Induced Seizures After Voluntary C-4 Ingestion." 01/01/2023 - "These findings confirm that RDX induces seizure activity via inhibition of the α1β2γ2 GABAAR and support the use of GABAAR-targeted anti-seizure drugs for the treatment of RDX-induced seizures." 01/01/2023 - "To determine whether this mechanism translates in vivo, we established a larval zebrafish model of RDX-induced seizures. " 01/01/2023 - "When ingested in large enough quantity, RDX causes tonic-clonic seizures. "
2.	Insulin Resistance 12/01/2015 - "RDX decreased plasma and renal tissue noradrenaline (norepinephrine) levels and BP. RDX also improved glucose metabolism and insulin sensitivity, which was associated with increased in vivo glucose uptake by peripheral tissues. "
3.	Shock 10/01/2018 - "Theoretical study for anisotropic responses of the condensed-phase RDX under shock loadings." 05/09/2018 - "We have performed molecular dynamics simulations in conjunction with the multiscale shock technique (MSST) to study the initial chemical processes of condensed-phase RDX under various shock velocities (8 km s-1, 10 km s-1 and 11 km s-1). " 08/21/2017 - "In the current study, RDX was re-crystallized and spheroidized to form the high-quality RDX that was further characterized by purity, apparent density, size distribution, specific surface area, impact sensitivity, and shock sensitivity. " 10/04/2012 - "This work complements previous studies on RDX at HP-HT conditions and provides comprehensive results on the reactive behavior of γ-RDX; the γ-phase plays a key role in RDX decomposition at P-T conditions relevant to shock wave initiation." 08/30/2012 - "This study has established the important role that γ-RDX plays in decomposition of RDX under static and shock compression conditions; thus theoretical modeling of RDX decomposition at high pressures and temperatures needs to incorporate the γ-phase response."
4.	Hypertension (High Blood Pressure) 05/01/2011 - "To determine whether selective sympathetic activation to the kidneys contributes to hypertension development, additional studies were performed in renal denervated (RDX) and sham-denervated (Sham-DX) rats. " 12/01/2015 - "Recent clinical studies have shown that renal sympathetic denervation (RDX) improves glucose metabolism in patients with resistant hypertension. " 01/01/1990 - "Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal denervation (RDX). "
5.	Neoplasms (Cancer) 09/01/2006 - "army munitions formulations since World War II. Two-year carcinogenicity studies revealed RDX to be noncarcinogenic in two strains of rats, but a 2-year carcinogenicity study in B6C3F1 mice revealed an increased incidence of hepatocellular neoplasms in females. " 03/01/2015 - "PKCη/Rdx-driven phosphorylation of PDK1: a novel mechanism promoting cancer cell survival and permissiveness for parvovirus-induced lysis." 11/01/2012 - "Evaluations of the cancer weight of evidence and possible modes of action (MOA) for RDX-induced cancer were conducted. " 02/01/2012 - "Assessing the non-cancer risk for RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) using physiologically based pharmacokinetic (PBPK) modeling." 09/01/2006 - "The increased incidence of hepatocellular neoplasms in female mice given RDX at 35 mg/kg/day was interpreted as equivocal evidence of a carcinogenic effect."

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Norepinephrine (Noradrenaline)
3.	Midazolam (Versed)
4.	Zolpidem (Ambien)
5.	cyclonite (RDX)
6.	MicroRNAs (MicroRNA)
7.	nitramine (tetryl)
8.	Explosive Agents (Explosives)
9.	radixin
10.	Trinitrotoluene (TNT)

Related Therapies and Procedures

1.	Sympathectomy (Sympathectomies)
2.	Lasers (Laser)
3.	Compressed Air
4.	Length of Stay
5.	Denervation