2,3-dihydroxybenzoic acid

RN given refers to parent cpd

Also Known As:

2,3-dihydroxy benzoic acid; 2,3-dihydroxybenzoate; 2-pyrocatechuic acid; 2-pyrocatechuic acid, sodium salt; dihydroxybenzoic acid; ferri-2,3-dihydroxybenzoic acid; o-pyrocatechuic acid

Networked: 61 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Hydroxybenzoates: 18
        2,3-dihydroxybenzoic acid: 61
        Benzoates: 426
        Hydroxybenzoates: 18
        2,3-dihydroxybenzoic acid: 61
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxybenzoates: 18
      - 2,3-dihydroxybenzoic acid: 61
  - Carbocyclic Acids
    - Benzoates: 426
      - Hydroxybenzoates: 18
        2,3-dihydroxybenzoic acid: 61

Experts

1.	Lin, Mao-Tsun: 9 articles (08/2013 - 03/2002)
2.	Hsu, Chuan-Chih: 3 articles (11/2009 - 03/2007)
3.	Chang, Ching-Ping: 3 articles (07/2008 - 03/2007)
4.	Qi, Jianhua: 2 articles (01/2016 - 11/2014)
5.	Niu, Chiang-Shan: 2 articles (08/2013 - 02/2009)
6.	Wang, Hongbin: 1 article (08/2021)
7.	Wang, Jiayi: 1 article (08/2021)
8.	Wu, Zhaoxia: 1 article (08/2021)
9.	Yu, Yougui: 1 article (08/2021)
10.	Zhang, Yangyang: 1 article (08/2021)

Related Diseases

1.	Neoplasms (Cancer) 02/10/2009 - "To clarify whether aspirin is potentially carcinogenic, we investigated the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), which is correlated with the incidence of cancer, in cultured cells treated with 2,3-dihydroxybenzoic acid (2,3-DHBA), a metabolite of aspirin. " 05/10/2020 - "Recent reports have demonstrated that the aspirin metabolites 2,3-dihydroxybenzoic acid (2,3-DHBA), 2,5-dihydroxybenzoic acid (2,5-DHBA) and the flavonoid metabolites 2,4,6-trihydroxybenzoic acid (2,4,6-THBA), 3,4-dihydroxybenzoic acid (3,4-DHBA) and 3,4,5-trihydroxybenzoic acid (3,4,5-THBA) were effective in inhibiting cancer cell growth in vitro. " 03/01/1986 - "However EDTA, EGTA, 2,3-dihydroxybenzoic acid (2,3-DBA), Rhodotorulic acid, 8-hydroxyquinoline (8-Hq), catechin and Desferal, and other chelators failed to show sensitization of these tumor cells towards HU. "
2.	Ischemia 08/31/2007 - "The ischemia-induced increase in the ratio of 2,3-dihydroxybenzoic acid concentration relative to baseline did not differ significantly between preconditioned and control groups. " 09/01/1997 - "The contents of dihydroxybenzoic acid (DHBA) were increased at 15 min after ischemia and remained high for 30 min after reperfusion. " 06/01/2018 - "Furthermore, the level of 2,3-dihydroxybenzoic acid was significantly lower in the memantine group than in the control group during ischemia and reperfusion. " 07/25/2003 - "We measured the cerebral 2,3-dihydroxybenzoic acid (DHBA) level as the amount of hydroxyl radical production using a microdialysis technique with salicylic acids trapping during ischemia and reperfusion. " 06/29/2001 - "To observe the effect of hydroxyl radicals on neuronal damage in the hippocampus of SHRSP during ischemia and recirculation, we measured the levels of 2,3-dihydroxybenzoic acid (2,3-DHBA), as a biological marker of hydroxyl radicals in the hippocampus of SHRSP, by high pressure liquid chromatography-electrochemical detection. "
3.	Arthritis (Polyarthritis) 05/01/1952 - "[Trial use of o-pyrocatechuic acid in acute rheumatoid arthritis, in chronic evolutive polyarthritis and in certain pararheumatic disorders]." 03/01/1955 - "[Two years of trials of sodium 2,3-dihydroxybenzoate with cortisone in chronic evolutive polyarthritis]."
4.	Heat Stroke (Heatstroke) 02/28/2009 - "The cerebrovascular, renal, and hepatic dysfunction, the increased levels of nitric oxide metabolites, tumor necrosis factor-alpha, and dihydroxybenzoic acid in the serum during heatstroke were significantly reduced by WBC. " 03/01/2002 - "Concentrations of dihydroxybenzoic acid, lipid peroxidation, rate of O2*- generation, superoxide dismutase, and catalase activity of the brain or other vital organs were assessed during heatstroke. " 06/01/2007 - "The cerebrovascular dysfunction, the increased levels of nitric oxide metabolites, tumor necrosis factor-alpha, and dihydroxybenzoic acid in both the serum and the hypothalamus, and the increased levels of hypothalamic inducible nitric oxide synthase immunoreactivity occurred during heatstroke were significantly suppressed by brain cooling. " 06/01/2007 - "Compared with the normothermic controls, the 36 degrees C saline-treated heatstroke rats displayed higher levels of brain temperature, intracranial pressure, serum and hypothalamic nitric oxide metabolite, tumor necrosis factor-alpha and dihydroxybenzoic acid as well as hypothalamic inducible nitric oxide synthase immunoreactivity. " 02/01/2008 - "As compared with those of normothermic controls, all vehicle-treated heatstroke animals displayed higher levels of core temperature, intracranial pressure, and NO metabolite, glutamate, glycerol, lactate-pyruvate ratio, and dihydroxybenzoic acid in hypothalamus. "
5.	Poisoning 03/01/1995 - "In this study, the effects of HBO on generation of highly reactive hydroxyl radical (HO.) in the brain after CO poisoning in rats was investigated using nonenzymatic hydroxylation of salicylic acid to 2,3 dihydroxybenzoic acid (2,3-DHBA) as a probe. " 08/06/2004 - "Carbon monoxide (CO) poisoning caused by CO exposure at 3000 ppm for 40 min resulted in stimulation of hydroxyl radical (*OH) generation (estimated by measuring 2,3-dihydroxybenzoic acid (2,3-DHBA) production from salicylic acid) in the striatum of free-moving rats, as determined by means of brain microdialysis. "

Related Drugs and Biologics

1.	2,5-dihydroxybenzoic acid (gentisic acid)
2.	Aspirin (Acetylsalicylic Acid)
3.	Gallic Acid
4.	Flavonoids
5.	2,4,6-trihydroxybenzoic acid
6.	protocatechuic acid
7.	Hydroxyl Radical
8.	Salicylates
9.	Free Radicals
10.	Glutamic Acid (Glutamate)

Related Therapies and Procedures

1.	Therapeutics
2.	Chelation Therapy (Therapy, Chelation)
3.	Ligation
4.	Intramuscular Injections
5.	Aftercare (After-Treatment)