elevated levels in urine of cancer patients
Also Known As:
N2,N2-dimethylguanosine; m(2)(2)G; m(2)2G; m2(2)G
Networked: 12 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Dyavaiah, Madhu: 1 article (12/2010)
2. Taghizadeh, Koli: 1 article (12/2010)
3. Begley, Thomas J: 1 article (12/2010)
4. DeMott, Michael S: 1 article (12/2010)
5. Chan, Clement T Y: 1 article (12/2010)
6. Dedon, Peter C: 1 article (12/2010)
7. Raftery, Daniel: 1 article (10/2010)
8. Hammoud, Zane: 1 article (10/2010)
9. Kc, Ravi: 1 article (10/2010)
10. Djukovic, Danijel: 1 article (10/2010)

Related Diseases

1. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
2. Neoplasms (Cancer)
09/30/1993 - "From the fact that molar ratios of urinary N2,N2-dimethylguanosine (m2 2G)pseudouridine (psi) and t6A/psi in cancer patients were lower than those of normal or post-surgical cancer patients, the increase of rRNA content in cancer tissues growing rapidly was estimated using the stoichiometric relationship between the ratio of the number of residues of their modified nucleoside in RNAs and the proportion of rRNA to total RNAs in average tissues of whole body. "
06/01/1993 - "Levels of the modified nucleosides 1-methyl-adenosine, 2-methylguanosine, N2,N2-dimethylguanosine and 1-methylinosine as well as the total nucleoside level were elevated in the urine when a malignant tumour was present; the levels of N2,N2-dimethylguanosine were found to correlate with the stage of the cancer."
09/01/1977 - "Cancer patients and tumor-bearing animals excrete high levels of modified purines and pyrimidines some of which, e.g., N2,N2-dimethylguanosine, can originate only from transfer RNA (tRNA). "
01/01/2004 - "UV peaks evident in the chromatogram were examined by the various mass spectrometric techniques and adenosine, 1-methyladenosine, xanthosine, N1-methylguanosine, N2-methylguanosine, N2,N2-dimethylguanosine, N2,N2,N7-trimethylguanosine, inosine, and 1-methylinosine were each identified in the urine samples from cancer patients. "
10/30/2010 - "We quantified eight nucleosides using high-performance liquid chromatography/triple quadrupole mass spectrometry (HPLC/TQMS) and determined that the metabolic levels of 1-methyladenosine (p <2.14 × 10(-7)), N(2),N(2)-dimethylguanosine (p <2.78 × 10(-7)), N(2)-methylguanosine (p <2.48 × 10(-6)) and cytidine (p <6.98 × 10(-4)) were significantly elevated while the concentration of uridine (p <3.74 × 10(-3)) was significantly lowered in serum samples from cancer patients compared to those of control group. "
3. Colorectal Neoplasms (Colorectal Cancer)
4. Leukemia
5. Hypersensitivity (Allergy)

Related Drugs and Biologics

1. Pseudouridine
2. 1-methylinosine
3. 1-methylguanosine
4. Transfer RNA (tRNA)
5. Nucleosides
6. 7-methylguanosine
7. 1-methyladenosine
8. Biological Markers (Surrogate Marker)
9. Uridine
10. Pyrimidines