pimaric acid

RN given refers to (D)-isomer; structure

Also Known As:

Usic acid; pimara-8(14),15-dien-19-oic acid; pimaradienoic acid; pimaric acid, (L)-isomer; 1-Phenanthrenecarboxylic acid, 7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-, (1R-(1alpha,4abeta,4balpha,7beta,10aalpha))-

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - pimaric acid: 6

Experts

1.	Arakawa, Nilton S: 2 articles (01/2016 - 11/2014)
2.	Carvalho, Thacyana T: 2 articles (01/2016 - 11/2014)
3.	Casagrande, Rubia: 2 articles (01/2016 - 11/2014)
4.	Hohmann, Miriam S N: 2 articles (01/2016 - 11/2014)
5.	Mizokami, Sandra S: 2 articles (01/2016 - 11/2014)
6.	Possebon, Maria I: 2 articles (01/2016 - 11/2014)
7.	Staurengo-Ferrari, Larissa: 2 articles (01/2016 - 11/2014)
8.	Verri, Waldiceu A: 2 articles (01/2016 - 11/2014)
9.	Zarpelon, Ana C: 2 articles (01/2016 - 11/2014)
10.	de Souza, Anderson R: 2 articles (01/2016 - 11/2014)

Related Diseases

1.	Pain (Aches) 11/26/2014 - "Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway."
2.	Ovarian Neoplasms (Ovarian Cancer) 03/02/2022 - "Pimaric acid induced cytotoxicity in human ovarian cancer cells (PA-1) in a dose-dependent manner without causing too much cytotoxicity in human ovarian epithelial cells (T1074). " 03/02/2022 - "This investigation aimed to evaluate the anticancer effects of Pimaric acid and its molecular mechanism in human ovarian cancer cells. " 03/02/2022 - "However, the role of Pimaric acid in ovarian cancer is still not known. " 03/02/2022 - "Anticancer effects of Pimaric acid is mediated via endoplasmic reticulum stress, caspase-dependent apoptosis, cell cycle arrest, and inhibition of cell migration in human ovarian cancer cells."
3.	Osteoarthritis 05/17/2011 - "To investigate the chondroprotective effects of OAH19T on osteoarthritis was examined and compared with its major compounds pimaradienoic acid (PA) and ferulic acid (FA) of human osteoarthritis (OA) chondrocytes. "
4.	Hypotension (Low Blood Pressure) 04/01/2008 - "Pimaradienoic acid inhibits vascular contraction and induces hypotension in normotensive rats."
5.	Glioma (Gliomas) 02/01/2007 - "Forced BK channel opening within the glioma cells by BK channel activators (phloretin or pimaric acid) induced U251 glioma cell swelling and vacuolization occurred within 30 min. U251 glioma cell cytotoxicity, induced by using BK channel activators, required between 8 and 12 h. "

Related Drugs and Biologics

1.	Cytokines
2.	KATP Channels
3.	Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)
4.	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)
5.	Phloretin
6.	Nitric Oxide (Nitrogen Monoxide)
7.	Cyclic GMP
8.	Carrageenan
9.	Antineoplastic Agents (Antineoplastics)
10.	ferulic acid (sodium ferulate)