oxychlordane

metabolite of chlordan more toxic to mammals than parent cpd; structure

Also Known As:

1 alpha,2 beta,4 beta,5,6,7 beta,8,8-octachloro-2,3 alpha-epoxy-3a alpha,4,7,7a alpha-tetrahydro-4,7-methanoindan

Networked: 26 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Chlorinated Hydrocarbons: 240
      - Chlordan: 124
        oxychlordane: 26

Experts

1.	Klebanoff, Mark A: 3 articles (07/2014 - 03/2012)
2.	Longnecker, Matthew P: 3 articles (07/2014 - 03/2012)
3.	Engel, Lawrence S: 2 articles (11/2019 - 09/2015)
4.	Grimsrud, Tom K: 2 articles (11/2019 - 09/2015)
5.	Rothman, Nathaniel: 2 articles (11/2019 - 09/2015)
6.	Brock, John W: 2 articles (09/2013 - 03/2012)
7.	McGlynn, Katherine A: 2 articles (03/2012 - 05/2008)
8.	Itoh, Hiroaki: 2 articles (05/2010 - 07/2009)
9.	Iwasaki, Motoki: 2 articles (05/2010 - 07/2009)
10.	Tsugane, Shoichiro: 2 articles (05/2010 - 07/2009)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2004 - "Exposure of highly purified NK cells to 5 microM alpha-chlordane, gamma-chlordane, 4,4'-DDT, heptachlor, oxychlordane, or pentachlorophenol (PCP) inhibited their ability to destroy K562 tumor-cells by 88+/-5, 92+/-8, 61+/-13%, 64+/-10%, 69+/-11%, 76+/-12%, respectively, after a 24 h exposure. " 11/01/2006 - "In a previous study, we found that six organochlorine compounds (alpha-chlordane, gamma-chlordane, 4,4'-DDT, heptachlor, oxychlordane, and pentachlorophenol (PCP)), at concentrations of 5 microM, were able to significantly decrease the ability of highly purified human natural killer (NK) cells to lyse tumor cells after exposures, ranging from 1 hour to 6 days. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2000 - "Oxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer." 01/01/2000 - "This paper examines the hypothesis that environmental exposure to trans-nonachlor (TNC) and oxychlordane (OCD), a major metabolite of the insecticide chlordane, increases the A total of 304 histologically confirmed, incident primary breast-cancer patients and 186 histologically confirmed incident benign breast-disease controls were included in the study between 1994 and 1997. " 07/01/2009 - "No increase in the risk of breast cancer was seen among women with higher serum concentrations of any organochlorine: o,p'-DDT, p,p'-DDT, p,p'-dichlorodiphenyldichloroethylene, hexachlorobenzene, beta-hexachlorocyclohexane, trans-nonachlor, cis-nonachlor, oxychlordane, mirex, or PCBs. "
3.	Body Weight (Weight, Body) 02/01/2003 - "Female rats were gavaged with oxychlordane at doses ranging from 0.01 to 10 mg/kg body weight/day for up to 28 days. " 11/26/2005 - "Thus, comparative tissue depletion studies were undertaken in male and female rats exposed to trans-nonachlor, oxychlordane, or trans-chlordane at 2.5 mg/kg body weight/d by gavage for 28 d followed by two consecutive 28-d depletion periods. "
4.	Atherosclerosis 01/01/2016 - "DDE and oxychlordane were not associated with atherosclerosis. " 01/01/2016 - "In the current study, urinary concentrations of F2-isoprostanes and serum levels of persistent OC compounds p,p'-dichlorodiphenyldichloroethene (DDE), trans-nonachlor (a component of the technical chlordane mixture), and oxychlordane (a chlordane metabolite) were quantified in a cross-sectional study sample and the association of these factors with a clinical diagnosis of atherosclerosis determined. "
5.	Testicular Neoplasms (Testicular Cancer) 05/07/2008 - "To study the relationship of POP exposure to TGCT risk, prediagnostic serum samples from 754 case subjects and 928 control subjects enrolled in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study were analyzed for cis-nonachlor, trans-nonachlor, oxychlordane, total chlordanes, beta-hexachlorocyclohexane, mirex, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), and p,p'-dichlorodiphenyltrichloroethane. "

Related Drugs and Biologics

1.	nonachlor
2.	Chlordan (Chlordane)
3.	Dichlorodiphenyl Dichloroethylene (DDE)
4.	DDT
5.	Mirex
6.	beta-hexachlorocyclohexane
7.	Pentachlorophenol (Sodium Pentachlorophenate)
8.	Insecticides
9.	Heptachlor
10.	Persistent Organic Pollutants