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ouabagenin

inhibitor of ATPASE; structure

Also Known As:

1 beta,3 beta,5,11 alpha,14,19- hexahydroxy-5 beta-card-20(22)-enolide; g-strophanthidin

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cardanolides
      - Cardiac Glycosides: 1002
        Cardenolides: 137
        Strophanthins: 181
        Ouabain: 2233
        ouabagenin: 5
Carbohydrates: 22023
- Glycosides: 2119
  - Cardiac Glycosides: 1002
    - Strophanthins: 181
      - Ouabain: 2233
        ouabagenin: 5

Experts

1.	Kataoka, Takao: 1 article (01/2015)
2.	Okina, Yuji: 1 article (01/2015)
3.	Takada, Yohei: 1 article (01/2015)
4.	Takeuchi, Fumihiko: 1 article (01/2015)
5.	Yokomichi, Tomonobu: 1 article (01/2015)
6.	Baran, Phil S: 1 article (01/2013)
7.	Renata, Hans: 1 article (01/2013)
8.	Zhou, Qianghui: 1 article (01/2013)

Related Diseases

1.	Non-alcoholic Fatty Liver Disease 09/01/2023 - "Therapeutic effect of ouabagenin, a novel liver X receptor agonist, on atherosclerosis in nonalcoholic steatohepatitis in SHRSP5/Dmcr rat model."
2.	Atherosclerosis 09/01/2023 - "Therapeutic effect of ouabagenin, a novel liver X receptor agonist, on atherosclerosis in nonalcoholic steatohepatitis in SHRSP5/Dmcr rat model."
3.	Lung Neoplasms (Lung Cancer) 12/01/2022 - "In Silico Prospects and Therapeutic Applications of Ouabagenin and Hydroxylated Corticosteroid Analogues in the Treatment of Lung Cancer."
4.	Heart Failure 01/04/2013 - "Given the medicinal relevance of the cardenolides in the treatment of congestive heart failure, a variety of ouabagenin analogs could potentially be generated from the key intermediate as a means of addressing the narrow therapeutic index of these molecules. "
5.	Heart Arrest (Cardiac Arrest) 01/01/1996 - "RME inhibitors significantly delayed the cardiac arrest caused by ouabain and dihydroouabain but they did not modify the toxicity of 3 X 10(-7)M digitoxin or 5 X 10(-6)M ouabagenin. "

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
3.	Ouabain (G Strophanthin)
4.	Digoxigenin
5.	Digitoxin
6.	Digitoxigenin
7.	Cardenolides
8.	Adrenal Cortex Hormones (Corticosteroids)
9.	Liver X Receptors
10.	dihydroouabain