nuciferine

01/01/2015 - "Nuciferine, an active ingredient extracted from the natural lotus leaf, has been reported to be effective for the prevention and treatment of NAFLD. "
01/01/2020 - "Conversely, treatment with nuciferine improved the metabolic disorder in the NAFLD rat model. "
06/01/2022 - "The objective of this study was to investigate the effects of nuciferine, a major active component from lotus leaf, on NAFLD and its underlying mechanism of action. "
01/01/2020 - "In conclusion, our study demonstrated an amelioration of the metabolic disorders following nuciferine treatment in NAFLD rat model. "
01/01/2020 - "In this study, we established a NAFLD rat model using HFD and treated with nuciferine. "

01/01/2023 - "The current work provides a better understanding of the anti-inflammation properties of nuciferine against multiple diseases, thereby improving the utilization and application of nuciferine-containing plants across functional food and medicine."
01/01/2023 - "Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases."
06/01/2022 - "Histology confirmed that the leaf extract and nuciferine prevented structural abnormality and inflammation in heart and liver tissues of treated groups. "
10/22/2018 - "Our results suggested a potential molecular mechanism of the anti-inflammatory effects of nuciferine in LPS-induced inflammation, at least in part, by activating PPARα and PPARγ in RAW 264.7 cells."
09/28/2022 - "Our previous study showed that nuciferine (NF) attenuated non-alcoholic fatty liver disease (NAFLD), which is attributed to a high-fat diet (HFD) through reinforcing intestinal barrier functions, regulating lipid metabolism, and improving inflammation. "

07/01/2016 - "In this study we used a network pharmacology approach to identify the anti-tumor activity of nuciferine and the underlying mechanisms. "
07/01/2016 - "Target profile clustering results suggested that nuciferine to exert anti-tumor effect. "
07/01/2016 - "The anti-tumor mechanisms of nuciferine were predicted through network target analysis and verified by in vitro experiments. "
07/01/2016 - "The anti-tumor activity of nuciferine was validated by in vitro and in vivo experiments. "
07/01/2016 - "Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach."

01/01/2019 - "Nuciferine-treated significantly increased the body weight from 339.4g to 367.8g, but significantly decreased the food and water intake compared with diabetic rats. "
12/01/2020 - "The results showed that body weight, average daily weight gain, and absolute and relative fat and liver weight were significantly decreased with nuciferine supplementation. "
09/28/2022 - "Nuciferine and norcoclaurine significantly reduced blood glucose (p < 0.05) and restored body weight in diabetic rats. "
01/01/2020 - "The results showed that nuciferine treatment significantly reduced the body weight, levels of lipids, and liver enzymes in the blood and improved the hepatic steatosis in the NAFLD rat model. "
06/01/2022 - "Pretreatment with leaf extract and nuciferine (200 and 20 mg/kg body weight, respectively) against MI induced by isoproterenol (85 mg/kg body weight) significantly decreased heart weight; levels of cardiac markers such as lactate dehydrogenase and creatine kinase-MB were similar to those in controls. "

06/01/2022 - "Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway."
11/01/2018 - "Nuciferine restored impaired glucose tolerance and insulin resistance in diabetic mice. "
06/01/2022 - "Here we show that nuciferine activated ALP and alleviated steatosis, insulin resistance in the livers of NAFLD mice and palmitic acid-challenged hepatocytes in a TFEB-dependent manner. "
06/01/2022 - "Mechanistic investigation revealed that nuciferine interacts with the Ragulator subunit hepatitis B X-interacting protein and impairs the interaction of the Ragulator complex with Rag GTPases, thereby suppressing lysosomal localization and activity of mTORC1, which activates TFEB-mediated ALP and further ameliorates hepatic steatosis and insulin resistance. "
11/30/2023 - "In this work, we aimed to summarize the interesting results from preclinical and clinical studies that assessed the effects of natural alkaloids (berberine, nigelladine A, piperine, trigonelline, capsaicin, nuciferine, evodiamine, mahanine, and magnoflorine) on impaired insulin sensitivity and worsened insulin resistance, which play a pivotal role in the pathogenesis of type 2 diabetes. "