nobiletin

11/01/2020 - "Nobiletin ameliorates high-fat diet-induced vascular and renal changes by reducing inflammation with modulating AdipoR1 and TGF-β1 expression in rats."
01/01/2020 - "Our study evaluates the role of nobiletin in inflammation-mediated gastric carcinogenic signaling of H. "
06/01/2019 - "This study was to prove Nobiletin (NBT) inhibits inflammation-caused calcification of human valve interstitial cells (hVICs) and to elucidate the involved molecular mechanisms. "
05/01/2006 - "The purpose of this study was to investigate the effects of nobiletin, a polymethoxyflavonoid, on eosinophilic airway inflammation of asthmatic rats, and explore its possible mechanisms. "
10/01/2023 - "Nobiletin possesses several bioactivities such as anti-inflammation, antioxidation, and neuroprotection. "

03/01/2018 - "Taken together, our findings suggest that nobiletin plays a modulatory role in adipocytes via induction of browning in 3T3-L1 white adipocytes and activation of HIB1B brown adipocytes combined with amelioration of stress in adipocytes, thereby exhibiting therapeutic potential against obesity."
02/08/2023 - "Collectively, our findings uncover a novel activity of Nobiletin in suppressing adipocyte development, implicating its potential therapeutic application in countering obesity and its associated metabolic consequences."
01/01/2023 - "Collectively, our findings uncover a novel activity of Nobiletin in suppressing adipocyte development in a clock-dependent manner, implicating its potential application in countering obesity and associated metabolic consequences."
04/26/2021 - "These results suggested that the bidirectional interaction of nobiletin and gut microbiota played an important role on the anti-obesity effect of nobiletin."
04/26/2021 - "Nobiletin is abundant in citrus peels and demonstrates good anti-obesity bioactivity. "

02/01/2020 - "Nobiletin reversed PTX resistance in MDR tumor via increasing the PTX content in the MDR tumor and inhibiting AKT/ERK/Nrf2 pathways, but without affecting the systematic exposure of PTX, indicating that nobiletin may be an effective and safe MDR tumor reversal agent."
12/22/2015 - "Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells."
08/01/2006 - "To study the inhibitory effect and mechanism of nobiletin on Heps tumor bearing mice. "
07/01/2004 - "In the present study, intracellular target molecules associated with the actions of nobiletin against tumor invasion were identified. "
07/31/2023 - "Nobiletin (NOB) (5,6,7,8,3',4'-Hexamethoxyflavone) is a polymethoxyflavone that inhibits the proliferation and migration of various cancer cell types. "

01/01/2022 - "Nobiletin opposed the effects of the HFHC diet by normalizing intestinal de novo lipogenesis through improved insulin sensitivity. "
06/01/2010 - "The present study investigated the effects of nobiletin on insulin sensitivity in obese diabetic ob/ob mice, and the possible mechanisms involved. "
06/01/2018 - "Nobiletin protects against insulin resistance and disorders of lipid metabolism by reprogramming of circadian clock in hepatocytes."
01/01/2013 - "Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice."
06/01/2010 - "Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice."

02/01/2020 - "In this study, we investigated whether nobiletin had protective effects on inflammatory parameters, oxidative damage, iNOS-eNOS expressions, and histopathological structure of renal tissue in rats with renal ischemia-reperfusion injury. "
12/01/2020 - "Nobiletin alleviates ischemia/reperfusion injury in the kidney by activating PI3K/AKT pathway."
01/01/2019 - "Nobiletin alleviates cerebral ischemic-reperfusion injury via MAPK signaling pathway."
05/01/2017 - "Nobiletin ameliorates ischemia-reperfusion injury by suppressing the function of Kupffer cells after liver transplantation in rats."
09/01/2023 - "Corrigendum to "Nobiletin ameliorates myocardial ischemia and reperfusion injury by attenuating endoplasmic reticulum stress-associated apoptosis through regulation of the PI3K/AKT signal pathway" [Int. "