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nitrosocarbaryl
combination of food additive sodium nitrite with carbaryl (SEVIN) results in formation of acid solution of potent mutagen; RN given refers to unlabeled parent cpd
Also Known As:
1-naphthyl-N-methyl-N-nitrosocarbamate; N-nitrosocarbaryl; nitrosocarbaryl, 13N-labeled cpd; Carbamic acid, methylnitroso-, 1-naphthalenyl ester
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
Carbaryl: 138
nitrosocarbaryl: 6
Carboxylic Acids: 973
Acyclic Acids
Carbamates: 945
Carbaryl: 138
nitrosocarbaryl: 6
Nitroso Compounds: 446
Nitrosamines: 1539
nitrosocarbaryl: 6
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
Carbaryl: 138
nitrosocarbaryl: 6
Related Diseases
1.
Neoplasms (Cancer)
01/01/1981 - "
Nitrosocarbaryl gave rise to skin tumors in eight mice.
"
05/01/1976 - "
A higher total dose of nitrosocarbaryl, 1.3 mmol, given to male rats twice weekly for 20 weeks did not produce a higher incidence of stomach tumors than did thelower dose in females, although the males died earlier with tumors.
"
05/01/1976 - "
The rats given nitrosocarbaryl survived longer, but had as high an incidence of tumors (75%) as did rats given nitrosomethylurethane.
"
2.
Body Weight (Weight, Body)
05/01/1976 - "
N-Nitrosocarbaryl was administered orally to 31 male Sprague-Dawley rats at doses of 130 mg/kg body weight (b.w.) twice weekly.
"
07/01/1980 - "
N-Nitrosocarbaryl (N-methyl-1-naphthyl N-nitrosocarbamate) was intraperitoneally administered to male and female rats on four consecutive days at the following doses: 6.25 mg, 12.5 mg, 25 mg and 50 mg/kg body weight/day in olive oil solution; the controls received just the oil.
"
3.
Xeroderma Pigmentosum (Kaposi's Disease)
08/01/1976 - "
Human skin cells (both normal and xeroderma pigmentosum) were treated with carbaryl (N-methyl-1-naphthyl-carbamate), a common agricultural pesticide, or its N-nitroso derivative, nitrosocarbaryl, and the DNA of the cells was sedimented in alkaline sucrose gradients at several times after treatment.
"
4.
Chromosome Aberrations (Chromosome Abnormalities)
01/01/1980 - "
Six alkylarylnitrosoureas were checked for induction of chromosome aberrations and SCEs in Chinese hamster V79-E cells and compared with MNU, ENU and nitrosocarbaryl.
"
Related Drugs and Biologics
1.
Sucrose (Saccharose)
2.
Solutions
3.
Carbaryl (Sevin)
4.
Pesticides
5.
Nitrosomethylurethane
6.
DNA (Deoxyribonucleic Acid)
7.
Olive Oil
Related Therapies and Procedures
1.
Aftercare (After-Treatment)