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induces GTPase activity of EF-TU; N-demethyl analog of antibiotic X-5108; structure
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Bio-Agent Context: Research Results
Heterocyclic Compounds: 60
1-Ring Heterocyclic Compounds
02/01/1998 - "
Ribosomes have different conformations in cells that are starved for a required amino acid (giving aminoacyl.tRNA starvation), or treated with kirromycin (blocking EF-Tu.GDP release), or are in exponential growth.
03/03/1981 - "
Ammonium dependence of the GTPase activity an increased affinity for GTP are two properties also found with wild-type EF-Tu in the presence of kirromycin [Fasano, O., Burns, W., Crechet, J.-B., Sander, G., & Parmeggiani, A.
Related Drugs and Biologics
Peptide Elongation Factor Tu (EF-Tu)
GTP Phosphohydrolases (GTPases)
Transfer RNA (tRNA)
Guanosine Triphosphate (GTP)
Guanosine Diphosphate (GDP)
Quaternary Ammonium Compounds (Ammonium)
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