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mocimycin

induces GTPase activity of EF-TU; N-demethyl analog of antibiotic X-5108; structure

Also Known As:

delvomycin; kirromycin

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Pyridones: 14
      - mocimycin: 3

Experts

1.	Bakowski, Malina A: 1 article (01/2019)
2.	Duan, Yanwen: 1 article (01/2019)
3.	Fang, Shi-Ming: 1 article (01/2019)
4.	Huang, Yong: 1 article (01/2019)
5.	Hull, Mitchell V: 1 article (01/2019)
6.	Jiang, Yi: 1 article (01/2019)
7.	McNamara, Case W: 1 article (01/2019)
8.	Rateb, Mostafa E: 1 article (01/2019)
9.	Shen, Ben: 1 article (01/2019)
10.	Xu, Zhengren: 1 article (01/2019)

Related Diseases

1.	Starvation 02/01/1998 - "Ribosomes have different conformations in cells that are starved for a required amino acid (giving aminoacyl.tRNA starvation), or treated with kirromycin (blocking EF-Tu.GDP release), or are in exponential growth. "
2.	Nematode Infections 01/01/2019 - "These results suggest kirromycin is an effective lead scaffold, further exploration of which could potentially lead to the development of novel treatments for filarial nematode infections."
3.	Burns 03/03/1981 - "Ammonium dependence of the GTPase activity an increased affinity for GTP are two properties also found with wild-type EF-Tu in the presence of kirromycin [Fasano, O., Burns, W., Crechet, J.-B., Sander, G., & Parmeggiani, A. "

Related Drugs and Biologics

1.	Peptide Elongation Factor Tu (EF-Tu)
2.	Ammonium Compounds
3.	GTP Phosphohydrolases (GTPases)
4.	Transfer RNA (tRNA)
5.	Guanosine Triphosphate (GTP)
6.	Guanosine Diphosphate (GDP)
7.	Amino Acids