|1.||Ross, Brian M: 4 articles (10/2004 - 09/2003)|
|2.||Bonina, Francesco: 3 articles (05/2008 - 02/2003)|
|3.||Puglia, Carmelo: 3 articles (05/2008 - 02/2003)|
|4.||Scott-Thomas, Amy: 2 articles (09/2013 - 05/2013)|
|5.||Epton, Michael: 2 articles (09/2013 - 05/2013)|
|6.||Sauer, Heinrich: 2 articles (08/2010 - 08/2007)|
|7.||Smesny, Stefan: 2 articles (08/2010 - 08/2007)|
|8.||Leopold, Claudia S: 2 articles (12/2006 - 12/2006)|
|9.||Remane, Yvonne: 2 articles (12/2006 - 12/2006)|
|10.||Glen, Iain: 2 articles (10/2004 - 09/2003)|
02/01/2009 - "Finally the efficacy of PD-Feverfew was confirmed clinically by a reduction in erythema in a methyl nicotinate-induced vasodilation model. "
01/01/2006 - "In the current study, we evaluated the use of a minimal erythema concentration (MEC) of methyl nicotinate, defined as the lowest concentration that produces a complete and even erythema at the test site, compared with a 36.5-mM concentration of methyl nicotinate. "
08/01/2007 - "The cutaneous erythema induced by a low concentration of methyl nicotinate was detected only in subjects with fair to very fair skin defined by ITA> or =40 degrees. "
08/01/2007 - "This research aims at assessing the influence of baseline skin colour on the ability of reflectance spectrophotometry to detect cutaneous erythema induced by a low concentration of methyl nicotinate (2.5 mM) (first objective), and to detect tanning induced by ultraviolet rays (UVA+UVB) at infra-erythemal doses (second objective). "
12/01/2006 - "Drug penetration experiments with methyl nicotinate in two different lipophilic vehicles were performed according to the FDA guidance for corticosteroid bioequivalence testing measuring the cutaneous erythema and skin temperature response. "
03/01/2003 - "The formulation of the lipophilic ointment was optimized, and the activity of this preparation was verified in methyl-nicotinate-induced contact urticaria and UV-induced erythema obtaining good results in terms of efficacy and safety."
02/01/1998 - "At the same time, their capacity to develop non-immunologic contact urticaria was evaluated using chemicals of different structural type and urticant ability: methyl nicotinate, benzoic acid, cinnamic acid, cinnamaldehyde and dimethyl sulfoxide (DMSO). "
04/01/1987 - "To investigate the mechanisms of non-immunologic contact urticaria (NICU), the effect of 120 mg of terfenadine (H1-antagonist) on contact reactions to methyl nicotinate, diethyl fumarate, benzoic acid, cinnamic acid, cinnamic aldehyde and dimethyl sulfoxide was studied in 20 subjects. "
03/01/1987 - "To investigate the mechanisms of non-immunologic contact urticaria (NICU), the effects of 1g + 1g of acetylsalicylic acid (ASA) on contact reactions to methyl nicotinate, diethyl fumarate, benzoic acid, cinnamic acid, cinnamic aldehyde and dimethyl sulfoxide were studied in 21 test subjects. "
01/01/1986 - "In the present study we examined the effects of chlorpheniramine and ranitidine, indomethacin, BW755C (an inhibitor of cyclo-oxygenase and lipo-oxygenase enzymes of arachidonic acid metabolism), dexamethasone, and capsaicin on nonimmunologic contact urticaria (NICU) induced in the guinea pig ear by benzoic, acid cinnamic acid, cinnamic aldehyde, methyl nicotinate, diethyl fumarate, or dimethyl sulfoxide. "
10/01/1998 - "Reactors showed a significantly increased intensity of response to methyl nicotinate as early as 5 min after application, and for 30 min afterwards, though the duration of inflammation in these 2 groups was the same. "
10/01/1998 - "The intensity and duration of inflammation generated by methyl nicotinate were used to assess penetration of this chemical in persons with sensitive skin compared to those with normal skin. "
05/01/1990 - "Thirty minutes after excess drug removal, skin inflammation was induced by a 1-min application of methyl nicotinate (3 mM). "
10/01/1989 - "The NSAID are initially applied to the skin under occlusion before inflammation is induced by a methyl nicotinate solution. "
05/01/1990 - "The aim of this study was to compare the activities of the two main classes of topical anti-inflammatory drugs in methyl-nicotinate-induced skin inflammation, using a new methodology based on laser-Doppler velocimetry. "
|4.||Schizophrenia (Dementia Praecox)
09/01/2010 - "Eight concentrations of methylnicotinate were applied to the forearms of 20 adults with schizophrenia and 20 controls. "
05/01/2004 - "In conclusion, reduced methyl nicotinate response in schizophrenia has been demonstrated using an objective measure of vasodilation. "
05/01/2004 - "In addition, it is unknown whether methylnicotinate insensitivity is specific to schizophrenia. "
05/01/2004 - "The normal vasodilatory response to topically applied methylnicotinate has been reported to be absent or reduced in patients with schizophrenia, a finding thought to be related to aberrant phospholipid metabolism. "
09/01/2003 - "The methylnicotinate insensitivity in schizophrenia, however, is likely to be due to a deficiency in the fatty acid precursors required for the vasodilatory reaction."
05/01/1992 - "Histamine induced a wheal and edema in all subjects, while methylnicotinate only caused erythema. "
09/01/1988 - "NSAIDs had significant inhibitory effects on erythema induced by all 4 substances tested and on edema induced by methyl nicotinate. "
05/01/1992 - "In the present study, we investigated the influence of induced hyperemia produced by methylnicotinate and histamine respectively, both vasodilators but only histamine giving edema. "
|1.||Benzoic Acid (Ucephan)
|2.||Niacin (Nicotinic Acid)
|3.||Dimethyl Sulfoxide (DMSO)
|5.||cinnamic aldehyde (cinnamaldehyde)
|7.||Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
|10.||Arachidonic Acid (Vitamin F)