5-methoxyindole-2-carboxylic acid

inhibitor of gluconeogenesis; structure

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

1.	Stroke (Strokes) 01/01/2018 - "Post-ischemic administration of 5-methoxyindole-2-carboxylic acid at the onset of reperfusion affords neuroprotection against stroke injury by preserving mitochondrial function and attenuating oxidative stress." 01/01/2020 - "Previous studies determined that treatment with 5-methoxyindole-2-carboxylic acid (MICA) conferred chemical preconditioning and neuroprotection against stroke. "
2.	Ischemic Stroke 01/01/2020 - "Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke." 12/01/2017 - "Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury."
3.	Hypoglycemia (Reactive Hypoglycemia) 03/07/1977 - "This hypoglycemia was mostly abolished by phentolamine, an alpha-adrenolytic agent, or by hexamethonium; was potentiated by propranolol, a beta-adrenolytic agent, of by 5-methoxyindole-2-carboxylic acid, a gluconeogenic inhibitor; and was not affected by anti-insulin serum. "
4.	Hyperglycemia 02/01/1984 - "5-Methoxyindole-2-carboxylic acid (MICA), an inhibitor of gluconeogenesis, blocked EPI- and apomorphine-induced hyperglycemia in rats fasted for 18 hr. However, 5-methoxyindole-2-carboxylic acid was ineffective in blocking hyperglycemia in animals fasted for 2 hr. Changes in insulin or glucagon in serum alone cannot account for the hyperglycemic action of apomorphine. "

1.	mica
2.	Insulin (Novolin)
3.	Hexamethonium (Hexamethonium Bromide)
4.	Propranolol (Inderal)
5.	Phentolamine (Z-Max)
6.	Dihydrolipoamide Dehydrogenase (Lipoamide Dehydrogenase)
7.	Glucagon (Glukagon)
8.	Apomorphine