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3-mercaptopicolinic acid

gluconeogenesis inhibitor; may also inhibit ATP-dependentphosphoenolpyruvate carboxykinase

Also Known As:

3-mercapto-2-pyridinecarboxylic acid; 3-mercaptopicolinate; SK&F 34288; SKF 34288

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Picolinic Acids: 1
      - 3-mercaptopicolinic acid: 11
- Heterocyclic Acids
  - Picolinic Acids: 1
    - 3-mercaptopicolinic acid: 11

Experts

1.	McCarty, M F: 1 article (03/2001)
2.	Burger, H J: 1 article (01/2000)
3.	Herling, A W: 1 article (01/2000)
4.	Preibisch, G: 1 article (01/2000)
5.	Simon, C: 1 article (01/2000)

Related Diseases

1.	Hypoglycemia (Reactive Hypoglycemia) 01/01/1987 - "The inhibition of hepatic gluconeogenesis by 3-mercaptopicolinic acid (3-MPA) leads to a profound hypoglycemia in both suckling and fasting 24-hour-old rabbits. " 07/01/1995 - "The effects of glycerol on tumor growth, animal survival during systemic hypoglycemia induced by 3-mercaptopicolinic acid (3-MP, a gluconeogenesis inhibitor), and effects of 3-MP on gluconeogenesis from glycerol were studied. " 01/15/2000 - "A similar pattern of hypoglycemia and possibly of associated counterregulatory responses elicited by treatment with the phosphoenolpyruvate carboxykinase inhibitor 3-mercaptopicolinic acid could account for only a 2-fold induction of Glc-6-Pase mRNA. " 03/01/2001 - "Unfortunately, when Burt used 3-mercaptopicolinate to inhibit gluconeogenesis and thereby induce hypoglycemia in fasted tumor-bearing subjects, infused glycerol served as gluconeogenic substrate, raising the serum glucose level. "
2.	Neoplasms (Cancer) 07/01/1995 - "The effects of glycerol on tumor growth, animal survival during systemic hypoglycemia induced by 3-mercaptopicolinic acid (3-MP, a gluconeogenesis inhibitor), and effects of 3-MP on gluconeogenesis from glycerol were studied. " 03/01/2001 - "Unfortunately, when Burt used 3-mercaptopicolinate to inhibit gluconeogenesis and thereby induce hypoglycemia in fasted tumor-bearing subjects, infused glycerol served as gluconeogenic substrate, raising the serum glucose level. "
3.	Hyperthyroidism 11/01/1987 - "3. Use of 3-mercaptopicolinate indicated that the glucose released from liver of hyperthyroid rats was synthesized from substrates metabolized via the gluconeogenic pathway. " 10/01/1984 - "In the presence of lactate and pyruvate, 3-mercaptopicolinate (3-MPA) (an inhibitor of gluconeogenesis) did not affect lipogenesis in hepatocytes from fed control rats but substantially increased lipogenesis in hepatocytes from starved euthyroid rats or fed hyperthyroid rats. "
4.	Starvation 09/01/1983 - "Direction of carbon flux in starvation and after refeeding: in vitro and in vivo effects of 3-mercaptopicolinate."
5.	Insulin Resistance 11/01/1987 - "By this time, glucose production exhibited pH, 3-mercaptopicolinate, and insulin sensitivity. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Glycerol (Glycerine)
3.	Lactic Acid (Lactate)
4.	Pyruvic Acid (Pyruvate)
5.	Messenger RNA (mRNA)
6.	Phosphoenolpyruvate