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mast cell degranulating peptide

isolated from bee venoms; made up of 22 amino acids; has 2 disulfide bridges

Also Known As:

mcd peptide; peptide 401

Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - mast cell degranulating peptide: 14

Experts

1.	Buku, A: 2 articles (09/2005 - 12/2001)
2.	Price, J A: 2 articles (09/2005 - 12/2001)
3.	Kim, Woo-Jin: 1 article (03/2022)
4.	Lee, Si Hyeock: 1 article (03/2022)
5.	Yoon, Kyungjae Andrew: 1 article (03/2022)
6.	Francese, Simona: 1 article (01/2009)
7.	Lambardi, Duccio: 1 article (01/2009)
8.	Mastrobuoni, Guido: 1 article (01/2009)
9.	Moneti, Gloriano: 1 article (01/2009)
10.	Turillazzi, Stefano: 1 article (01/2009)

Related Diseases

1.	Seizures (Absence Seizure) 07/11/1997 - "Both the Mast Cell Degranulating (MCD) peptide and Dendrotoxin I (DTX(I)), two blockers of fast activation and slowly inactivating K+ channels, induced epileptiform seizures and brain damage after intracerebroventricular injection (200 pmol) in Sprague-Dawley rats. " 08/21/1989 - "Intracerebroventricular injection of mast-cell degranulating peptide (MCD), dendrotoxin I (DTXI) and 4-aminopyridine (4-AP), 3 blockers of a subclass of K+ channel, produces seizures and convulsions. " 02/07/1991 - "Using electroencephalographic (EEG) recordings in freely moving rats and extracellular neuronal firing-rate recordings in hippocampal slices, we examined the effects of riluzole (RP 54274), a compound with anti-glutamate properties, against the convulsive seizures and the cellular hyperexcitability produced by the mast-cell degranulating peptide (MCD), dendrotoxin I (DTXi) and 4-aminopyridine (4-AP). " 08/21/1989 - "Both the bee venom toxin, mast cell degranulating (MCD) peptide, and the snake toxin, dendrotoxin 1 (DTX1) induce epileptiform activity and paroxystic seizures after intracerebroventricular (i.c.v.) injection to rats. "
2.	Pain (Aches) 12/22/2022 - "mellifera apamin and mast cell-degranulating peptide, did not contribute to pain behaviours in mice. " 03/01/2022 - "For example, genes encoding most of the allergens (dipeptidyl peptidase 4, endocuticle structural glycoprotein, odorant-binding protein, phospholipase A1, A2, B1, serine protease, serine protease inhibitor and venom allergen 5), pain-producing factor (mast cell degranulating peptide), and paralyzing factor (neprilysin) commonly exhibited decreasing expression patterns in all of the hymenopteran species tested, except for some of the major venom genes in Apis mellifera and Bombus ignitus, which showed an increasing pattern. "
3.	Leukemia 12/01/2001 - "These labeled analogs were used in rat basophilic leukemia cells (RBL-2H3) to demonstrate by confocal microscopy and flow cytometry the specific binding of MCD peptide to mast cell receptors. " 09/01/2005 - "In contrast to MCD peptide, [Ala12]MCD showed a 50% inhibition of IgE binding to the Fc epsilon RI alpha mast cell receptor by using rat basophilic leukemia (RBL-2H3) mast cells and fluorescence polarization. "
4.	Inflammation (Inflammations) 06/01/1992 - "These analogs were synthesized by solid-phase methods and were compared to MCD peptide in two assays for inflammation: histamine release from mast cells and superoxide anion release from neutrophils. " 01/01/1999 - "The solid phase synthesis of mast degranulating peptide (MCD peptide) raised the possibility of preparing analogs and examining the pharmacology and the proposed role of this peptide as a potential agent in allergy and inflammation. " 01/01/1999 - "Mast cell degranulating (MCD) peptide: a prototypic peptide in allergy and inflammation."
5.	Hypersensitivity (Allergy) 01/01/1999 - "The solid phase synthesis of mast degranulating peptide (MCD peptide) raised the possibility of preparing analogs and examining the pharmacology and the proposed role of this peptide as a potential agent in allergy and inflammation. " 01/01/1999 - "Mast cell degranulating (MCD) peptide: a prototypic peptide in allergy and inflammation." 09/01/2005 - "An effort was made to discover mast cell degranulating (MCD) peptide analogs that bind with high affinity to mast cell receptors without triggering secretion of histamine or other mediators of the allergic reaction initiated by immunoglobulin E (IgE) after mast cell activation. "

Related Drugs and Biologics

1.	dendrotoxin I
2.	4-Aminopyridine (4 Aminopyridine)
3.	Venoms
4.	Histamine (Histamine Dihydrochloride)
5.	Carrageenan
6.	Allergens
7.	Serine Proteases (Serine Protease)
8.	Phospholipases A1 (Phospholipase A1)
9.	Riluzole
10.	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)

Related Therapies and Procedures

1.	Intradermal Injections
2.	Denervation
3.	Adrenalectomy