4-(N-maleimido)benzyltrimethylammonium (MPTA)

affinity-alkylating agent; RN given refers to parent cpd
Also Known As:
MPTA; 4-(N-maleimido)benzyltrimethylammonium iodide; benzenemethanaminium, 4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-N,N,N-trimethyl-
Networked: 20 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Devor, M: 5 articles (05/2008 - 10/2001)
2. Sukhotinsky, I: 4 articles (05/2008 - 12/2006)
3. Devor, Marshall: 3 articles (01/2016 - 09/2005)
4. Kronenberg, Jona: 3 articles (09/2011 - 02/2005)
5. Reiner, K: 3 articles (05/2008 - 12/2006)
6. Dou, Shuping: 2 articles (05/2008 - 02/2008)
7. Liu, Guozheng: 2 articles (05/2008 - 02/2008)
8. Hnatowich, Donald J: 2 articles (05/2008 - 02/2008)
9. Rusckowski, Mary: 2 articles (05/2008 - 02/2008)
10. Hopkins, D A: 2 articles (03/2007 - 12/2006)

Related Diseases

1. Neoplasms (Cancer)
2. Pain (Aches)
3. Congenital Abnormalities (Deformity)
4. Unconsciousness (Loss of Consciousness)
01/01/2016 - "Combined with the prior microinjection data, we conclude that drug delivery to the MPTA is sufficient to induce loss-of-consciousness and that neurons in this locus are necessary for anesthetic induction at clinically relevant doses. "
03/01/2007 - "Using neuroanatomical tracing we identified four pathways ascending from the MPTA that are positioned to mediate electroencephalographic synchronization and loss of consciousness: (i) projections to the intralaminar thalamic nuclei that, in turn, project to the cortex; (ii) projections to several pontomesencephalic, diencephalic and basal forebrain nuclei that project cortically and are considered parts of an ascending "arousal system"; (iii) a projection to other parts of the subcortical forebrain, including the septal area, hypothalamus, zona incerta and striato-pallidal system, that may indirectly affect cortical arousal and hippocampal theta rhythm; and (iv) modest projections directly to the frontal cortex. "
05/27/2009 - "Microinjection of pentobarbital into a restricted region of rat brainstem, the mesopontine tegmental anesthesia area (MPTA), induces a reversible anesthesia-like state characterized by loss of the righting reflex, atonia, antinociception, and loss of consciousness as assessed by electroencephalogram synchronization. "
05/25/2007 - "However, we found that microinjection of GABAA-receptor (GABAA-R) active anesthetics into a restricted locus in the rat brainstem, the mesopontine tegmental anesthesia area (MPTA), rapidly induces a reversible anesthesia-like state characterized by suppressed locomotion, atonia, anti-nociception and loss of consciousness. "
05/20/2008 - "Microinjection of pentobarbital or other gamma-aminobutyric acid type A receptor (GABA(A)-R) active anesthetics into a brainstem region in the rat that we have called the mesopontine tegmental anesthesia area (MPTA) induces a general anesthesia-like state that includes suppression of locomotor activity, loss of the righting reflex, atonia, antinociception, and apparent loss of consciousness. "
5. Genu Varum

Related Drugs and Biologics

1. Antibodies
2. Pentobarbital (Nembutal)
3. Anesthetics (Anesthetic Agents)
4. gamma-Aminobutyric Acid (GABA)
5. GABA-A Receptor Agonists
6. GABA-A Receptors (GABA(A) Receptor)
7. B72.3 antibody

Related Therapies and Procedures

1. Osteotomy
2. Anesthesia
3. Cochlear Implantation
4. Electrodes (Electrode)
5. General Anesthesia