limonene (d-limonene)

colorless liquid with a citrus-like odor; found in large number of oils; the most common terpene and is produced by hundreds of plants; dissolving agent for gall stones & gutta-percha; used in surfactant as a penetration enhancer; structure

Also Known As:

Networked: 200 relevant articles (11 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Karlberg, Ann-Therese: 7 articles (05/2014 - 11/2002)
2.	Börje, Anna: 5 articles (05/2014 - 06/2005)
3.	Chow, H-H Sherry: 4 articles (01/2015 - 11/2002)
4.	White, Ian R: 4 articles (11/2014 - 06/2005)
5.	Johansen, Jeanne D: 4 articles (11/2014 - 06/2005)
6.	Bruze, Magnus: 4 articles (11/2014 - 06/2005)
7.	Garcia-Bravo, Begoña: 4 articles (11/2014 - 11/2002)
8.	Andersen, Klaus E: 4 articles (11/2014 - 06/2005)
9.	Anesini, Claudia: 4 articles (02/2010 - 11/2008)
10.	Goossens, An: 4 articles (11/2006 - 11/2002)

Related Diseases

1.	Carcinoma (Carcinomatosis) 07/01/1994 - "These studies are consistent with the above studies in that limonene is effective in preventing mammary carcinomas with activated ras. " 07/01/1994 - "In the first study, we asked whether dietary limonene was able to prevent the development of mammary carcinomas which were induced using direct retroviral gene transfer of v-Ha-ras into the mammary parenchyma in situ. " 07/15/1997 - "In week 26, quantitative histological analysis showed that prolonged treatment with d-limonene significantly reduced the number of pancreatic carcinomas. " 11/15/1996 - "Monoterpene-induced/repressed genes were identified in regressing rat mammary carcinomas treated with dietary limonene using a newly developed method termed subtractive display. " 07/01/1994 - "As expected, limonene administration increased the latency period and lowered the frequency of mammary carcinoma development as compared to controls. "
2.	Inflammation 03/01/2014 - "These studies show that d-Limonene and POH demonstrate significant anti-inflammatory effects in murine dermal inflammation and wound-healing. " 08/01/2012 - "D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis." 05/01/2012 - "Limonene inhalation reduces allergic airway inflammation in Dermatophagoides farinae-treated mice." 07/10/2013 - "Protective effects on the epithelial barrier and decreased cytokines are involved, suggesting a beneficial role of d-Limonene as diet supplement in reducing inflammation." 04/01/2014 - "D-limonene suppresses doxorubicin-induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats."
3.	Neoplasms (Cancer) 09/01/2007 - "Subsequent studies have determined how these tumors occur and established that d-limonene does not pose a mutagenic, carcinogenic, or nephrotoxic risk to humans. " 05/01/2005 - "In vitro studies indicate that D-limonene increased NO production in peritoneal macrophages obtained from tumor-bearing mice. " 05/01/2005 - "The monoterpene D-limonene and its metabolites have been shown to exert chemopreventive and chemotherapeutic activities against different tumors in animal models and clinical trials. " 01/01/2015 - "While of interest as a cancer chemopreventive, the biologic activity of limonene in humans is poorly understood. " 07/01/2014 - "This component has shown chemopreventive and therapeutic activity against a wide variety of experimental tumors, but D-limonene is unstable and lose its lemon-like flavor under normal storage condition, and it is almost insoluble in water. "
4.	Dermatitis 03/01/2014 - "Two murine models of respectively 12-O-Tetradecanoylphorbol-13-Acetate (TPA)-induced dermatitis and mechanical skin lesion were used here to assess the efficacy of d-Limonene or POH applied topically. " 11/01/2014 - "To study the exposure to limonene among consecutive dermatitis patients reacting to oxidized R-limonene in an international setting, and to assess the relevance of the exposure for the patients' dermatitis. " 11/01/2006 - "The current study extends these investigations to 6 European clinics of dermatology, where the oxidation mixture of both enantiomers of limonene (R and S) have been tested in 2411 dermatitis patients. " 11/01/2014 - "Oxidized R-limonene is a common fragrance allergen, and limonene was frequently found in the labelling on the patients' products, and assessed as relevant for the patients' dermatitis. " 11/01/2014 - "Overall, exposure to products containing limonene was found and assessed as being probably relevant for the patients' dermatitis in 36% of the limonene-allergic patients. "
5.	Asthma (Bronchial Asthma) 05/01/2012 - "The aim of this study was to evaluate whether limonene can inhibit Dermatophagoides farinae-induced airway hyperresponsiveness (AHR), eosinophilic infiltration and other histological changes in the lung, T helper (Th) 2 cytokine production and airway remodeling in a mice model of asthma. " 05/01/2012 - "These results indicate that limonene has a potential to reduce airway remodeling and AHR in asthma model." 05/01/2008 - "Allergic contact dermatitis and asthma caused by limonene in a labourer handling citrus fruits." 04/01/2010 - "These results suggest that limonene may have potential anti-inflammatory efficacy for the treatment of bronchial asthma by inhibiting cytokines, ROS production, and inactivating eosinophil migration." 01/15/2015 - "BALB/c mice pretreated by inhalation of d-limonene before an ovalbumin challenge exhibited significant attenuation of the allergic asthma symptoms. "

Related Drugs and Biologics

1.	Cytokines
2.	perilla alcohol (perillyl alcohol)
3.	anthracene
4.	Biological Markers (Surrogate Marker)
5.	Vitamin E
6.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
7.	Oleic Acid (Oleate)
8.	NF-kappa B (NF-kB)
9.	Insulin (Novolin)
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Oral Administration
2.	Chemoprevention
3.	Ovariectomy (Oophorectomy)
4.	Caloric Restriction
5.	Injections