15-keto-13,14-dihydroprostaglandin F2alpha (PGFM)

main metabolite of PGF2alpha in plasma after allergen provoked asthma; RN given refers to (5Z,9alpha,11alpha)-isomer; structure

Also Known As:

PGFM; 13,14-dihydro-15-keto-PGF2alpha; 13,14-dihydro-15-ketoprostaglandin F; 13,14-dihydro-15-ketoprostaglandin F2alpha; 13,14-dihydro-15-oxoprostaglandin F; 15-K-DH-PGF(2alpha); 15-keto-13,14-dihydro-PGF2alpha; 15-keto-13,14-dihydro-prostaglandin F2alpha; 15-keto-dihydro-PGF2alpha; DHK-PGF2alpha; pulmonary metabolite-PGF2alpha; (5Z,9 alpha, 11 alpha)-9,11-dihydroxy-15-oxoprost-5-en-1-oic acid

Networked: 83 relevant articles (3 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Basu, Samar: 8 articles (07/2007 - 03/2003)
2.	Matsui, Motozumi: 3 articles (12/2018 - 08/2008)
3.	Miyamoto, Akio: 3 articles (12/2018 - 08/2008)
4.	Berg, Kirsti: 3 articles (10/2006 - 05/2004)
5.	Jynge, Per: 3 articles (10/2006 - 05/2004)
6.	Skarra, Sissel: 3 articles (10/2006 - 05/2004)
7.	Wiseth, Rune: 3 articles (10/2006 - 05/2004)
8.	Kindahl, H: 2 articles (05/2010 - 12/2009)
9.	Acosta, Tomas J: 2 articles (03/2009 - 08/2008)
10.	Ishii, Mitsuo: 2 articles (03/2009 - 08/2008)

Related Diseases

1.	Premature Obstetric Labor (Premature Labor) 04/01/1986 - "The mean initial PGFM level was significantly higher in patients who delivered preterm (65.9 +/- 9.7 pg/mL; N = 14) than in patients not in preterm labor (32.1 +/- 4.3 pg/mL; N = 11; P less than .01). " 02/01/1981 - "Excluding this patient, preterm labor PGFM concentrations were significantly lower (P less than .05) than those at term. " 06/01/1978 - "The concentration of PGFM in plasma from patients in preterm labor (62.7 +/- 17.4 pg/ml) was not significantly different from that found during late pregnancy, but was significantly lower than levels found at term during early labor (P less than 0.05). " 04/01/1986 - "Two of four patients not considered to be in preterm labor but who delivered prematurely (within five days of initial evaluation) had initial PGFM concentrations of greater than 55 pg/mL. Concentration determinations of PGFM might be a useful adjunct in identifying early preterm labor and in predicting success of tocolytic therapy." 01/01/1989 - "Amniotic fluid concentrations of PGFM and PGEM-ll were significantly greater in women with preterm labor and intra-amniotic infection than in women without infection. "
2.	Infections 02/01/1994 - "These data indicate that plasma PGFM concentrations are greater in postpartum cows with spontaneous uterine infections then in herdmates free of infection." 02/01/1994 - "Postpartum Holstein (n=21) and Jersey (n=4) cows were used to determine if uterine infections are associated with elevated plasma concentrations of 13,14-dihydro-15-keto-prostaglandin F(2)alpha (PGFM). " 04/01/1987 - "Increases in PGFM concentrations prior to luteolysis in SC cows were associated with moderate to heavy infection. " 01/01/1987 - "Therefore, uterine infections in cows during the puerperium was associated with elevated circulating PGFM levels. " 01/01/1989 - "In addition, patients unresponsive to tocolysis without intra-amniotic infection also had a significantly greater concentration of PGFM and PGEM-ll in amniotic fluid than those responsive to tocolysis. "
3.	Neoplasms (Cancer) 01/01/2021 - "Comparing those patient eyes treated exclusively with PGFM versus those treated exclusively with MH, efficacy for tumor control and globe salvage was equivalent (PGFM vs. MH: 96.2% vs. 93.8%, p = 0.56), but PGFM-treated eyes received fewer injections than MH-treated eyes (average 3.2 ± 1.9 vs. 6.4 ± 2.1 injections, p < 0.0001). " 01/01/2021 - "In separate experiments to assess toxicity, three weekly 12.5 μg injections of MH, PGFM, or saline were administered to non-tumor-bearing rabbits. " 04/01/2011 - "Sixteen tumors were further sub-classified as pregnancy tumors (PT) and seventeen as pyogenic granulomas with fibrosis (PGFM). "
4.	Endometriosis 06/01/1982 - "Prostanoid concentrations (PGE2, PGF2 alpha, PGFM, TXB2) in women with endometriosis were not significantly different from a comparable group of disease-free women. " 06/01/1982 - "Cul-de-sac fluid from women with histologically confirmed endometriosis (n = 45) or with no evidence of endometriosis (n = 17) was removed during the proliferative phase of the menstrual cycle (days 8 to 12) and analyzed for prostaglandin E2 (PGE2), prostaglandin F2 alpha (PGF2 alpha), 15-keto-13,14-dihydroprostaglandin F2 alpha (PGFM), and thromboxane B2 (TXB2). "
5.	Retained Placenta 03/01/2009 - "The OT concentration was increased before placental expulsion in all the mares, and the PGFM concentration also increased in the two mares with retained placentas. " 09/01/1992 - "Cows with retained placentas and fed grass silage had less PGFM (2172 vs 4530 pg/ml; P<0.05) than cows without retained placentas and fed the same forage. " 09/01/1987 - "The results indicate that prepartal PGFM and cortisol increases may constitute reliable indicators of retained placenta in dairy cows." 09/01/1997 - "It may be concluded that a large amount of PGF2 alpha is released for a relatively shorter period in cows after dystocia and/or retained placenta and the elevation of PGFM is not responsible for the uterine involution. " 09/01/1997 - "A group of 27 cows with dystocia and/or retained placenta showed a massive release of PGF2 alpha after parturition as indicated by a rise of plasma concentrations of PGFM, significantly higher than 33 cows with normal puerperium. "

Related Drugs and Biologics

1.	Dinoprost
2.	Prostaglandins
3.	Dinoprostone (PGE2)
4.	Oxytocin (Pitocin)
5.	Prostaglandins F
6.	Progesterone
7.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
8.	Prostaglandins E
9.	C-Reactive Protein
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Tocolysis
2.	Injections
3.	Intravitreal Injections
4.	Catheters
5.	Cardiopulmonary Resuscitation (CPR)