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acarboxyprothrombin (PIVKA)

inactive precursor of prothrombin, activated via vitamin K-dependent addition of gamma carboxy groups
Also Known As:
PIVKA; DCP (prothrombin); PIVKA (protein induced by vitamin K absence or antagonists ); PIVKA II; PIVKA-II; PIVKA-II (protein induced by vitamin K absence or antagonist-II); acarboxy prothrombin; decarboxyprothrombin; des(gamma-carboxy)prothrombin; des-gamma-carboxy prothrombin; descarboxylated prothrombin; descarboxyprothrombin; isoprothrombin; non-carboxylated factor II; prothrombin precursor; pre-blood-coagulation factor II
Networked: 457 relevant articles (9 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Kokudo, Norihiro: 9 articles (04/2012 - 05/2003)
2. Kudo, Masatoshi: 8 articles (04/2012 - 12/2006)
3. Kim, Do Young: 7 articles (03/2016 - 01/2007)
4. Ahn, Sang Hoon: 7 articles (03/2016 - 01/2007)
5. Han, Kwang-Hyub: 7 articles (03/2016 - 01/2009)
6. Joh, Jae-Won: 7 articles (11/2015 - 06/2013)
7. Kim, Jong Man: 6 articles (11/2015 - 06/2013)
8. Taketomi, Akinobu: 6 articles (10/2015 - 12/2004)
9. Kumada, Takashi: 6 articles (06/2014 - 09/2007)
10. Toyoda, Hidenori: 6 articles (06/2014 - 09/2007)

Related Diseases

1. Hepatocellular Carcinoma (Hepatoma)
2. Neoplasms (Cancer)
3. Neoplasm Metastasis (Metastasis)
11/01/2009 - "In February 2005, the adrenal lesion enlarged to 5 cm in diameter and the value of PIVKA-II became high on blood examination, so April 2005, a surgical resection was performed, and it was diagnosed as the metastasis from HCC. "
12/01/2007 - "In PIVKA II-positive HCC, the frequencies of an infiltrative growth type (positive : negative = 62% : 28%, P < 0.001), vascular invasion (positive : negative = 63% : 26%, P < 0.001), and intrahepatic metastasis (positive : negative = 38% : 4%, P < 0.001) were significantly higher than in PIVKA II-negative HCC. "
01/01/2007 - "A univariate analysis revealed that Child-Pugh classification B (P = 0.002), a high des-gamma-carboxy prothrombin concentration (> or =400 mAU/ml, P = 0.023), a large HCC (> or =5.0 cm in diameter, P = 0.002), the presence of portal vein invasion (P < 0.001), the presence of venous trunk invasion (P = 0.048), the presence of intrahepatic metastasis (P < 0.001), and poorly differentiated HCC (P = 0.006) correlated with a worse overall survival after hepatic resection. "
10/01/2004 - "Soon after the treatments, PVTT was reduced in size and the serum level of PIVKA-II was decreased to 57 mAU/ml. After three months, the level of PIVKA-II had increased again and the size of the right adrenal metastasis grew to 50 mm in diameter. "
05/01/2011 - "With multivariate analysis, (1) preoperatively, positive factors of two or more among three items of PIVKA-II, L3-AFP, and deviancy from MC; (2) and postoperatively, pathological cancer spread (microscopic vascular invasion and/or intrahepatic metastasis) both represented risks for early recurrence. "
4. Fibrosis (Cirrhosis)
5. Pain (Aches)

Related Drugs and Biologics

1. alpha-Fetoproteins (AFP)
2. Vitamin K
3. lentil lectin
4. Antibodies
5. P 11 (P-11)
6. Biological Tumor Markers (Tumor Markers)
7. Prothrombin (Factor II)
8. Proteins (Proteins, Gene)
9. Osteocalcin
10. Vitamin K 1 (Phylloquinone)

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Hepatectomy
3. Surgical Instruments (Clip)
4. Liver Transplantation
5. Perioperative Period