isometheptene

RN given refers to cpd without isomeric designation; structure in Merck Index, 9th ed, #5040

Also Known As:

Midrid; N,1,5-trimethyl-4-hexenylamine; isometheptene monohydrochoride; isometheptene, (+-)-isomer; isometheptene, maleate; isometheptene, maleate(+-)-isomer; isometheptene, monomaleate; isometheptene, monomaleate(+-)-isomer; isometheptene, monotartrate; isometheptene, mucate (2:1); N,6-dimethyl-5-hepten-2-amine

Networked: 18 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Methylamines: 15
    - isometheptene: 18

Experts

1.	Daugherty, Bruce L: 1 article (12/2017)
2.	Hernández-Abreu, Oswaldo: 1 article (12/2017)
3.	Labastida-Ramírez, Alejandro: 1 article (12/2017)
4.	MaassenVanDenBrink, Antoinette: 1 article (12/2017)
5.	Rubio-Beltrán, Eloísa: 1 article (12/2017)
6.	Villalón, Carlos M: 1 article (12/2017)
7.	Marmura, Michael J: 1 article (01/2015)
8.	Schwedt, Todd J: 1 article (01/2015)
9.	Silberstein, Stephen D: 1 article (01/2015)
10.	Buse, Dawn C: 1 article (01/2013)

Related Diseases

1.	Migraine Disorders (Migraine) 10/01/1975 - "Isometheptene--a non-ergot drug in the treatment of migraine." 08/04/1972 - "Midrid for migraine?" 09/01/1985 - "Autonomic dysreflexia due to medication: misadventure in the use of an isometheptene combination to treat migraine." 12/01/2017 - "Isometheptene is a sympathomimetic drug effective in acute migraine treatment. " 02/01/1972 - "A double-blind crossover trial of isometheptene mucate compound and ergotamine in migraine."
2.	Headache (Headaches) 12/01/1993 - "A postpartum patient, initially presenting with headaches, subsequently manifested rapid neurological deterioration after ingesting isometheptene, a sympathomimetic drug. " 01/01/2013 - "We determined whether these individuals had consulted a health care professional for headache over the previous year, if they ever received a medical diagnosis of migraine from a health care professional, and whether they were currently using appropriate acute treatment for migraine (ie, a triptan, prescription non-steroidal anti-inflammatory drug, or an isometheptene-containing agent). " 02/01/2012 - "We conclude that, despite failing to meet the primary outcome, the combination of dipyrone, isometheptene and caffeine is effective for the acute treatment of mild-to-moderate primary headache episodes, with excellent tolerability." 02/01/2012 - "Efficacy and tolerability of combined dipyrone, isometheptene and caffeine in the treatment of mild-to-moderate primary headache episodes." 02/01/2012 - "The efficacy and tolerability of a combination of dipyrone 600 mg, isometheptene 60 mg and caffeine 60 mg for the acute treatment of mild-to-moderate episodic primary headaches were evaluated against paracetamol 1000 mg and placebo. "
3.	Epilepsy (Aura) 04/01/2001 - "To compare the safety and efficacy of isometheptene mucate, dichloralphenazone with acetaminophen to sumatriptan succinate for the treatment of mild-to-moderate migraine, with or without aura, when taken at the first sign of an attack. "
4.	Cerebral Hemorrhage 11/01/2009 - "Physicians must be aware of the potential for this complication, and inquire about the use of isometheptene in unexplained cerebral hemorrhages. " 11/01/2006 - "Intracerebral hemorrhage in postpartum cerebral angiopathy associated with the use of isometheptene." 11/01/2009 - "Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy." 11/01/2009 - "A 45 year old female with no stroke risk factors suffered a massive intracerebral hemorrhage (ICH) after ingesting Midrin--a combination of isometheptene mucate, dichlorophenazine and acetaminophen. "
5.	Stroke (Strokes) 11/01/2009 - "A 45 year old female with no stroke risk factors suffered a massive intracerebral hemorrhage (ICH) after ingesting Midrin--a combination of isometheptene mucate, dichlorophenazine and acetaminophen. "

Related Drugs and Biologics

1.	Acetaminophen (Paracetamol)
2.	dichloralantipyrine
3.	Sumatriptan (Imigran)
4.	Sympathomimetics (Sympathomimetic Amines)
5.	Caffeine (No Doz)
6.	Dipyrone (Metamizole)
7.	Ergotamine (Ergotamine Tartrate)
8.	Midrin
9.	Propranolol (Inderal)
10.	Aspirin (Acetylsalicylic Acid)

Related Therapies and Procedures

1.	Therapeutics